Humoral immune response and safety of SARS-CoV-2 vaccination in very early onset inflammatory bowel disease

被引：0

作者：

Kastl, Arthur J. ^{[1
]}

Weaver, Kimberly N. ^{[2
]}

Zhang, Xian ^{[3
]}

Strople, Jennifer A. ^{[4
]}

Adler, Jeremy ^{[5
]}

Kelsen, Judith R. ^{[1
]}

Dubinsky, Marla C. ^{[6
]}

Bousvaros, Athos ^{[7
]}

Watkins, Runa ^{[8
]}

Dai, Colin ^{[2
]}

Cross, Raymond K. ^{[9
]}

Higgins, Peter D. R. ^{[10
]}

Ungaro, Ryan ^{[11
]}

Bewtra, Meenakshi ^{[12
]}

Bellaguarda, Emanuelle A. ^{[13
]}

Farraye, Francis A. ^{[14
]}

Chun, Kelly ^{[15
]}

Zikry, Michael ^{[15
]}

Bastidas, Monique ^{[15
]}

Boccieri, Margie E. ^{[3
]}

Firestine, Ann ^{[3
]}

Long, Millie D. ^{[2
,16
]}

Kappelman, Michael D. ^{[3
,16
]}

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Gastroenterol Hepatol & Nutr, 3500 Civ Ctr Blvd, Philadelphia, PA 19104 USA

[2] Univ N Carolina, Dept Med, Div Gastroenterol & Hepatol, Chapel Hill, NC USA

[3] Univ N Carolina, Dept Pediat, Div Pediat Gastroenterol, Chapel Hill, NC USA

[4] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL USA

[5] Univ Michigan, Susan B Meister Child Hlth Evaluat & Res Ctr, Dept Pediat, Ann Arbor, MI USA

[6] Icahn Sch Med, Susan & Leonard Feinstein IBD Ctr, Dept Pediat, Mt Sinai, NY USA

[7] Childrens Hosp, Boston, MA USA

[8] Univ Maryland, Sch Med, Div Pediat Gastroenterol & Nutr, Baltimore, MD USA

[9] Univ Maryland, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD USA

[10] Univ Michigan, Dept Med, Div Gastroenterol & Hepatol, Ann Arbor, MI USA

[11] Icahn Sch Med Mt Sinai, Susan & Leonard Feinstein IBD Clin Ctr, Dept Med, New York, NY USA

[12] Univ Penn, Dept Med, Div Gastroenterol & Hepatol, Philadelphia, PA USA

[13] Northwestern Univ, Div Gastroenterol & Hepatol, Chicago, IL USA

[14] Mayo Clin, Div Gastroenterol & Hepatol, Jacksonville, FL USA

[15] LabCorp, Esoterix Specialty Lab, Calabasas, CA USA

[16] Univ N Carolina, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC USA

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2024年 / 78卷 / 04期

关键词：

COVID-19; vaccine; antibody; Pfizer; Moderna; IMMUNODEFICIENCY;

D O I：

10.1002/jpn3.12142

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Children with very early onset inflammatory bowel disease (VEO-IBD) may respond differently to coronavirus disease 2019 (COVID-19) immunization compared to healthy children or other patients with IBD. We recruited children with VEO-IBD <6 years of age and younger following receipt of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. Demographics, IBD characteristics, medication use, adverse events (AEs) and IBD exacerbations were collected. Blood draws (optional) were obtained for measurement of antireceptor binding domain (RBD) IgG antibodies following vaccination. Of 41 participants, none required emergency department visit or hospitalization due to AE, and only one experienced IBD exacerbation. Detectable antibody was present in 19/19 participants who provided blood sample; 6/7 participants (86%) had durable humoral response 12 months postvaccination. Children with VEO-IBD experience robust humoral immune response to COVID-19 immunization. Severe AEs were rare. These findings provide reassurance that children with VEO-IBD respond well and safely to SARS-CoV-2 vaccination.

引用

页码：871 / 877

页数：7

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