Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis - a multicentre study

被引：5

作者：

Hegen, Harald ^{[1
]}

Berek, Klaus ^{[1
]}

Cavalla, Paola ^{[2
]}

Christiansen, Mikael ^{[3
]}

Emersic, Andreja ^{[4
]}

Di Filippo, Massimiliano ^{[5
]}

Gaetani, Lorenzo ^{[5
]}

Hassler, Michaela ^{[6
]}

Leurs, Cyra ^{[7
]}

Milosavljevic, Dejan ^{[6
]}

van Pesch, Vincent ^{[8
]}

Petersen, Thor ^{[9
]}

Presslauer, Stefan ^{[10
]}

Rosenstein, Igal ^{[11
]}

Rot, Uros ^{[4
,12
]}

Schnabl, Christine ^{[6
]}

Teunissen, Charlotte ^{[13
]}

Vecchio, Domizia ^{[14
]}

Vercellino, Marco ^{[2
]}

Deisenhammer, Florian ^{[1
]}

机构：

[1] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria

[2] AOU Citta Salute & Sci Torino, Multiple Sclerosis Ctr & Neurol IU, Dept Neurosci & Mental Hlth, Turin, Italy

[3] Reg Hosp Horsens, Dept Clin Biochem, DK-8700 Horsens, Denmark

[4] Univ Med Ctr Ljubljana, Dept Neurol, Ljubljana, Slovenia

[5] Univ Perugia, Dept Med & Surg, Sect Neurol, Perugia, Italy

[6] Univ Appl Sci, FH Campus Wien, Vienna, Austria

[7] Amsterdam UMC, Dept Neurol & Neurophysiol, Amsterdam Neurosci, VUMC, Amsterdam, Netherlands

[8] UCLouvain, Clin Univ St Luc, Brussels, Belgium

[9] Univ Hosp Southern Denmark, Sygehus Sonderjylland, Dept Reg Hlth Res, Hadersleben, Denmark

[10] Klinikum Ottakring, Dept Neurol, Vienna, Austria

[11] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Dept Clin Neurosci, Gothenburg, Sweden

[12] Univ Ljubljana, Fac Med, Ljubljana, Slovenia

[13] Vrije Univ, Dept Clin Chem, Neurochem Lab, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

[14] Maggiore Carita Univ Hosp, Dept Translat Med, Neurol Unit, Novara, Italy

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

欧盟地平线“2020”;

关键词：

cerebrospinal fluid; kappa free light chain; primary progressive; multiple sclerosis; diagnosis; sensitivity;

D O I：

10.3389/fimmu.2023.1327947

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BackgroundKappa free light chains (kappa-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).ObjectiveTo investigate whether kappa-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB).MethodsPatients with PPMS were recruited through 11 MS centres across 7 countries. kappa-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation.ResultsA total of 174 patients (mean age of 52 +/- 11 years, 51% males) were included. kappa-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients.Conclusion kappa-FLC index shows similar diagnostic sensitivity than OCB in PPMS.

引用

页数：6

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