Synthesis, Antibacterial, and Antimonooxidase Activity of 4-(2-Methyl-1,3-oxazol-5-yl)benzenesulfonamide

被引：1
|
作者：
Gasilina, O. A. [1 ,3 ]
Romanycheva, A. A. [1 ]
Shetnev, A. A. [1 ,2 ]
Korsakov, M. K. [1 ,3 ]
机构：
[1] KD Ushinsky Yaroslavl State Pedag Univ, Yaroslavl 150000, Russia
[2] Moscow Inst Phys & Technol, Dolgoprudnyi 141700, Russia
[3] Kosygin State Univ Russia, Moscow 115035, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 11期
基金：
俄罗斯科学基金会;
关键词：
sulfonamides; carbonic anhydrase inhibitors; antibiotic potentiation; anti-MAO effect; CARBONIC-ANHYDRASE IX; BENZENESULFONAMIDES; INHIBITORS; POTENT;
D O I：
10.1134/S1070363223110038
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new method for obtaining 4-(2-methyl-1,3-oxazol-5-yl)benzenesulfonamide, an antiglaucomatous drug candidate oxazopt, was developed using a diazotization reaction. A combined potentiated effect of the antimicrobial action of carbapenems (meropenem) and aminoglycosides (gentamicin) against antibiotic-resistant gram-positive bacteria Enterococcus faecium, Enterococcus faecalis and gram-negative bacteria Escherichia coli, and antimonooxidase effect in vitro was revealed for this compound.
引用
收藏
页码：2749 / 2755
页数：7
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