Synthesis, Antibacterial, and Antimonooxidase Activity of 4-(2-Methyl-1,3-oxazol-5-yl)benzenesulfonamide

被引：1

作者：

Gasilina, O. A. ^{[1
,3
]}

Romanycheva, A. A. ^{[1
]}

Shetnev, A. A. ^{[1
,2
]}

Korsakov, M. K. ^{[1
,3
]}

机构：

[1] KD Ushinsky Yaroslavl State Pedag Univ, Yaroslavl 150000, Russia

[2] Moscow Inst Phys & Technol, Dolgoprudnyi 141700, Russia

[3] Kosygin State Univ Russia, Moscow 115035, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 11期

基金：

俄罗斯科学基金会;

关键词：

sulfonamides; carbonic anhydrase inhibitors; antibiotic potentiation; anti-MAO effect; CARBONIC-ANHYDRASE IX; BENZENESULFONAMIDES; INHIBITORS; POTENT;

D O I：

10.1134/S1070363223110038

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method for obtaining 4-(2-methyl-1,3-oxazol-5-yl)benzenesulfonamide, an antiglaucomatous drug candidate oxazopt, was developed using a diazotization reaction. A combined potentiated effect of the antimicrobial action of carbapenems (meropenem) and aminoglycosides (gentamicin) against antibiotic-resistant gram-positive bacteria Enterococcus faecium, Enterococcus faecalis and gram-negative bacteria Escherichia coli, and antimonooxidase effect in vitro was revealed for this compound.

引用

页码：2749 / 2755

页数：7

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