Heavy consumption of garlic (Allium sativum) exert nephro- and pulmonary toxicity at maternal and embryonic level in the Albino rats

被引：1

作者：

Kamal, Zeinab ^{[1
]}

Al-Amgad, Zeinab ^{[2
]}

Zigo, Frantisek ^{[3
]}

Farkasova, Zuzana ^{[3
]}

Zigova, Martina ^{[4
,9
]}

Ahmad, Adel M. ^{[5
]}

Said, Alaa H. ^{[6
]}

Rehan, Ibrahim F. ^{[7
,8
,10
,11
]}

机构：

[1] South Valley Univ, Fac Sci, Zool Dept, Qena, Egypt

[2] Qena Vet Directorate, Gen Author Vet Serv, Qena, Egypt

[3] Univ Vet Med & Pharm, Dept Anim Nutr & Husb, Kosice, Slovakia

[4] P J Safarik Univ, Fac Med, Dept Pharmacol, Kosice, Slovakia

[5] South Valley Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Qena, Egypt

[6] South Valley Univ, Fac Sci, Elect & Nano Devises Lab, Qena, Egypt

[7] Menoufia Univ, Fac Vet Med, Dept Husb & Dev Anim Wealth, Shebin Alkom, Egypt

[8] Meijo Univ, Fac Pharm, Dept Pathobiochem, Nagoya, Japan

[9] P J Safarik Univ, Fac Med, Dept Pharmacol, Trieda SNP 1, Kosice 04011, Slovakia

[10] Menoufia Univ, Fac Vet Med, Dept Husb & Dev Anim Wealth, Shebin Alkom 32511, Egypt

[11] Meijo Univ, Fac Pharm, Dept Pathobiochem, Yagotoyama 150,Tempaku Ku, Nagoya, Aichi 4688503, Japan

来源：

JOURNAL OF APPLIED ANIMAL RESEARCH | 2023年 / 51卷 / 01期

关键词：

Bax; fetus; garlic; kidney; lung; ORGANOSULFUR COMPOUNDS; HERBAL MEDICINE; ANTIOXIDANT; HEALTH;

D O I：

10.1080/09712119.2023.2282518

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Despite the health benefits of herbals, random misuse of such therapy without consult tends to participate in public health issues. This study describes the nephro-and pulmonary toxicity effects of heavy consumption of garlic (Allium sativum) during developmental period. Two groups of ten healthy pregnant female Albino rats each were formed from the 20 in total. Gavages of distilled water were administered to the control group. Since garlic group rats orally received garlic aqueous extract (GAE) 1 ml/rat daily from gestational day (GD) 6 to 19. Kidney functions and lipid biomarkers were assayed along with histopathological investigations. Our results confirmed that the group that received garlic had significantly increased serum levels of urea, cholesterol, triglycerides and LDL. Moreover, the foetal and maternal tissues of the kidney and lung exhibited a varying degree of histopathological manifestations characterized by kidney necrosis and lung haemorrhage, severe congestion, and thickening of the blood vessels. Renal and pulmonary fibrosis were detectable by Masson's trichrome. A positive expression of the foetal kidney and placental tissues towards Bax protein was noticed. In conclusion, depending on existing findings, the administration of higher concentrations of garlic could explode renal and pulmonary toxicity and decrease the rat's weight.

引用

页码：776 / 788

页数：13