Supplementation of vitamin D reduces energy intake and prevents body fatness accumulation in obese woman

Introduction: Obese people are at higher risk of comorbidities, including metabolic syndrome, autoimmune, tumor progression and other inflammation diseases because of low-grade chronic inflammation. Vitamin D is closely related to transcriptional activity in adipose tissue, which regulates adipogenesis, inflammatory pathways, and adipose cell metabolism. This research aims to know the effect of Vitamin D supplementation on energy intake and body fat accumulation.Methods: 40 obese women between the ages of 26 and 45 were randomly assigned to the Intervention and Control groups, which received daily supplements of 5000 IU of vitamin D and a placebo, respectively. Data were gathered before the intervention and after 12 weeks of it. We measured the energy intake, BMI, waist circumference (WC), and conicity index. The participants were told to keep their daily calorie consumption at or below 1500 kcal.Results: After 12 weeks of supplementation, 25(OH) Vitamin D levels increased significantly (p=0.001), and energy intake decreased (p=0.014) significantly in the intervention group, but no change in the control group (p>0,05). Body fatness indices (BMI and WC) increased (p=0.005 and p=0.003) significantly in the control group; however, these parameters did not change in the intervention group (p>0.05).Conclusion: Daily Vitamin D 5000 IU for 12 weeks decreases energy intake and prevents body fat accumulation in obese women.