Orbitofrontal cortex conveys stimulus and task information to the auditory cortex

被引:5
作者
Mittelstadt, Jonah K. [1 ,2 ]
Kanold, Patrick O. [1 ,2 ,3 ]
机构
[1] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Kavli Neurosci Discovery Inst, Baltimore, MD 21205 USA
基金
美国国家卫生研究院;
关键词
SPECTROTEMPORAL RECEPTIVE-FIELDS; TO-NOISE RATIO; PREFRONTAL CORTEX; STARTLE RESPONSE; FRONTAL-CORTEX; PLASTICITY; ATTENTION; REWARD; LOCALIZATION; ORGANIZATION;
D O I
10.1016/j.cub.2023.08.059
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Auditory cortical neurons modify their response profiles in response to numerous external factors. During task performance, changes in primary auditory cortex (A1) responses are thought to be driven by top down inputs from the orbitofrontal cortex (OFC), which may lead to response modification on a trial-by-trial basis. While OFC neurons respond to auditory stimuli and project to A1, the function of OFC projections to A1 during auditory tasks is unknown. Here, we observed the activity of putative OFC terminals in A1 in mice by using in vivo two-photon calcium imaging of OFC terminals under passive conditions and during a tone detection task. We found that behavioral activity modulates but is not necessary to evoke OFC terminal responses in A1. OFC terminals in A1 form distinct populations that exclusively respond to either the tone, reward, or error. Using tones against a background of white noise, we found that OFC terminal activity was modulated by the signal-to-noise ratio (SNR) in both the passive and active conditions and that OFC terminal activity varied with SNR, and thus task difficulty in the active condition. Therefore, OFC projections in A1 are heterogeneous in their modulation of auditory encoding and likely contribute to auditory processing under various auditory conditions.
引用
收藏
页码:4160 / +
页数:19
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