Formulation and Characterization of Solid Lipid Nanoparticles Loaded with Troxerutin

Troxerutin (TXR), a naturally derived compound with diverse therapeutic potential, faces limitations in clinical efficacy due to poor bioavailability and rapid plasma clearance. This study focuses on troxerutin-loaded solid lipid nanoparticles (TXR-SLNs) and their physicochemical properties, intending to enhance drug release. TXR-SLNs were prepared via high-shear homogenization followed by ultrasonication, yielding optimized nanoparticles with an average size of 140.5 +/- 1.02 nm, a uniform distribution (polydispersity index: 0.218 +/- 0.01), and a stable emulsion (zeta potential: 28 +/- 8.71 mV). The formulation exhibited 83.62% entrapment efficiency, indicating improved drug-loading capacity and extended drug release. Spectroscopic and thermodynamic analyses confirmed component compatibility. Despite a decline in entrapment efficiency induced by temperature after one month of storage at 23 degrees C, the formulation may retain acceptable stability. This study provides insight into SLNs as effective carriers for enhancing troxerutin's release profile, motivating further in vivo investigations to optimize therapeutic interventions.