Comparison of the outcomes following bevacizumab and/or temozolamide/radiosurgery treatment in patients with glioblastoma

被引：3

作者：

Aravantinou-Fatorou, Aikaterini ^{[1
]}

Georgakopoulou, Vasiliki Epameinondas ^{[2
,3
]}

Mathioudakis, Nikolaos ^{[4
]}

Papalexis, Petros ^{[5
,6
]}

Tarantinos, Kyriakos ^{[7
]}

Trakas, Ilias ^{[1
]}

Trakas, Nikolaos ^{[8
]}

Spandidos, Demetrios A. ^{[9
]}

Fotakopoulos, George ^{[10
,11
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Med Sch, Dept Internal Med 1, Athens 11527, Greece

[2] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Med Sch, Dept Infect Dis, Athens 11527, Greece

[3] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Med Sch, Dept Internal Med 1,COVID 19 Unit, Athens 11527, Greece

[4] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Med Sch, Dept Renal Transplantat, Athens 11527, Greece

[5] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Med Sch, Dept Internal Med 1,Unit Endocrinol, Athens 11527, Greece

[6] Univ West Att, Dept Biomed Sci, Athens 12243, Greece

[7] Sismanogleio Hosp, Pulmonol Dept 1, Athens 15126, Greece

[8] Sismanogleio Hosp, Dept Biochem, Athens 15126, Greece

[9] Univ Crete, Sch Med, Lab Clin Virol, Iraklion 71003, Greece

[10] Gen Univ Hosp Larisa, Dept Neurosurg, Larisa 41221, Greece

[11] Gen Univ Hosp Larisa, Dept Neurosurg, Mezourlo 1, Larisa 41221, Greece

来源：

MOLECULAR AND CLINICAL ONCOLOGY | 2023年 / 19卷 / 03期

关键词：

radiotherapy; chemotherapy; temozolomide; bevacizumab; chemoradiotherapy; NEWLY-DIAGNOSED GLIOBLASTOMA; SINGLE-AGENT BEVACIZUMAB; PHASE-II TRIAL; RECURRENT GLIOBLASTOMA; ADJUVANT TEMOZOLOMIDE; RADIOTHERAPY; IRINOTECAN; PATTERNS; CARE; CONCOMITANT;

D O I：

10.3892/mco.2023.2669

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma multiforme (GBM) is the most frequent and malignant primary central nervous system tumor in adults. The gold-standard management of GBM includes post-operative radiotherapy (RT) with concurrent and secondary temozolomide (TMZ) treatment. The present meta-analysis study examined the efficacy of the early administration of bevacizumab prior to standard RT plus TMZ in managing patients with GBM and unfavorable prognostic factors. Between 1983 and 2020, the present study looked for comparative articles involving standard RT plus TMZ and RT/TMZ combined with bevacizumab treatment in patients with GBM. The primary outcomes involved in this study include progression-free survival and overall survival. The present study suggested that bevacizumab administration plus standard RT/TMZ (BEV group) treatment was associated with increased survival of patients with GBM compared with those treated with standard RT/TMZ (CG/Control group) treatment only.

引用

页数：6

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