Rutin modified selenium nanoparticles reduces cell oxidative damage induced by H2O2 by activating Nrf2/HO-1 signaling pathway

被引:12
作者
Zhu, Mengyu [1 ]
Zhang, Yang [1 ]
Zhang, Chi [1 ]
Chen, Lei [1 ,2 ]
Kuang, Ying [1 ,3 ]
机构
[1] Gannan Med Univ, Sch Basic Med, Ganzhou, Peoples R China
[2] Gannan Med Univ, Sch Pharm, Rongjiang New Area, Ganzhou 341000, Jiangxi, Peoples R China
[3] Gannan Med Univ, Sch Basic Med, Rongjiang New Area, Ganzhou 341000, Jiangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Alzheimer's disease; rutin; selenium; antioxidant activity; neuroprotection; ALZHEIMERS-DISEASE; INSIGHTS; BETA; SUPPLEMENTATION; STRESS; RATS;
D O I
10.1177/08853282231182765
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Oxidative damage of neurons is one of the key pathological markers of Alzheimer's disease (AD), which eventually leads to neuronal apoptosis and loss. Nuclear factor E2-related factor 2 (Nrf2) is a key regulator of antioxidant response and is considered to be an important therapeutic target for neurodegenerative diseases. In this study, the selenated derivative of antioxidant rutin (Se-Rutin) was synthesized with sodium selenate (Na2SeO3) as raw material by a simple electrostatic-compound in situ selenium reduction method. The effects of Se-Rutin on H2O2 induced oxidative damage in Pheochromocytoma PC12 cells were evaluated by cell viability, apoptosis, reactive oxygen species level and the expression of antioxidant response element (Nrf2). The results showed that H2O2 treatment significantly increased the level of apoptosis and reactive oxygen species, while the level of Nrf2 and HO-1 decreased. However, Se-Rutin significantly reduced H2O2 induced apoptosis and cytotoxicity, and increased the expression of Nrf2 and HO-1, both of which were better than that of pure rutin. Therefore, the activation of Nrf2/HO-1 signaling pathway may be the basis of Se-Rutin's anti-oxidative damage to AD.
引用
收藏
页码:109 / 121
页数:13
相关论文
共 51 条
  • [1] Neuroprotective Efficiency of Prodigiosins Conjugated with Selenium Nanoparticles in Rats Exposed to Chronic Unpredictable Mild Stress is Mediated Through Antioxidative, Anti-Inflammatory, Anti-Apoptotic, and Neuromodulatory Activities
    Albrakati, Ashraf
    Alsharif, Khalaf F.
    Al Omairi, Naif E.
    Alsanie, Walaa F.
    Almalki, Abdulraheem S. A.
    Abd Elmageed, Zakaria Y.
    Elshopakey, Gehad E.
    Lokman, Maha S.
    Bauomy, Amira A.
    Moneim, Ahmed E. Abdel
    Kassab, Rami B.
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021, 16 : 8447 - 8464
  • [2] Caniferolide A, a Macrolide from Streptomyces caniferus, Attenuates Neuroinflammation, Oxidative Stress, Amyloid-Beta, and Tau Pathology in Vitro
    Alvarino, Rebeca
    Alonso, Eva
    Lacret, Rodney
    Oves-Costales, Daniel
    Genilloud, Olga
    Reyes, Fernando
    Alfonso, Amparo
    Botana, Luis M.
    [J]. MOLECULAR PHARMACEUTICS, 2019, 16 (04) : 1456 - 1466
  • [3] Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling
    Amani, Hamed
    Habibey, Rouhollah
    Shokri, Fereshteh
    Hajmiresmail, Seyed Javad
    Akhavans, Omid
    Mashaghi, Alireza
    Pazoki-Toroudi, Hamidreza
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [4] Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease
    Bai, Renren
    Guo, Jianan
    Ye, Xiang-Yang
    Xie, Yuanyuan
    Xie, Tian
    [J]. AGEING RESEARCH REVIEWS, 2022, 77
  • [5] Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis
    Bloom, George S.
    [J]. JAMA NEUROLOGY, 2014, 71 (04) : 505 - 508
  • [6] Kallistatin: double-edged role in angiogenesis, apoptosis and oxidative stress
    Chao, Julie
    Li, Pengfei
    Chao, Lee
    [J]. BIOLOGICAL CHEMISTRY, 2017, 398 (12) : 1309 - 1317
  • [7] Choi YK., 2021, ALZHEIMERS DEMENT, V17, pe053516
  • [8] Alzheimer's disease drug development pipeline: 2022
    Cummings, Jeffrey
    Lee, Garam
    Nahed, Pouyan
    Kambar, Mina Esmail Zadeh Nojoo
    Zhong, Kate
    Fonseca, Jorge
    Taghva, Kazem
    [J]. ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, 2022, 8 (01)
  • [9] Developing Effective Alzheimer's Disease Therapies: Clinical Experience and Future Directions
    Elmaleh, David R.
    Farlow, Martin R.
    Conti, Peter S.
    Tompkins, Ronald G.
    Kundakovic, Ljiljana
    Tanzi, Rudolph E.
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2019, 71 (03) : 715 - 732
  • [10] Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
    Ferro, Claudio
    Florindo, Helena F.
    Santos, Helder A.
    [J]. ADVANCED HEALTHCARE MATERIALS, 2021, 10 (16)