Involvement of Metabolites and Non-coding RNAs in Diseases

被引：1

作者：

Coskun, Kubra A. ^{[1
]}

Kiyak, Bercem Yeman ^{[2
]}

Cifci, Kezban Ucar ^{[2
,3
]}

Kadioglu, Elif ^{[2
]}

Yurekli, Nazlican ^{[4
]}

Tutar, Yusuf ^{[5
,6
]}

机构：

[1] Istanbul Aydin Univ, Fac Med, Dept Basic Sci, Div Med Biol, Istanbul, Turkiye

[2] Univ Hlth Sci, Hamidiye Hlth Sci Inst, Div Mol Med, Istanbul, Turkiye

[3] Yozgat Bozok Univ, Hemp Res Inst, Div Basic Sci & Hlth, Yozgat, Turkiye

[4] Univ Hlth Sci, Hamidiye Fac Med, Dept Basic Sci, Div Med Biol, Istanbul, Turkiye

[5] Hamidiye Fac Pharm, Dept Basic Pharmaceut Sci, Div Biochem, Istanbul, Turkiye

[6] Univ Hlth Sci, Hamidiye Hlth Sci Inst, Div Mol Oncol, Istanbul, Turkiye

来源：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2023年 / 24卷 / 07期

关键词：

Metabolism; metabolites; metabolite analysis; non-coding; RNAs; disease; MASS-SPECTROMETRY; NATURAL-PRODUCTS; SYNTHETIC BIOLOGY; MICRORNAS; METABOLOMICS; DISCOVERY; CANCER; IDENTIFICATION; PSEUDOGENES; ACTIVATION;

D O I：

10.2174/1389201023666220921091240

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-coding RNAs have a role in gene regulation and cellular metabolism control. Metabolism produces metabolites which are small molecules formed during the metabolic process. So far, a direct relationship between metabolites and genes is not fully established; however, pseudogenes and their progenitor genes regulate health and disease states. Other non-coding RNAs also contribute to this regulation at different cellular processes. Accumulation and depletion of metabolites accompany the dynamic equilibrium of health and disease state. In this study, metabolites, their roles in the cell, and the link between metabolites and non-coding RNAs are discussed.

引用

页码：889 / 912

页数：24

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