Iliopsoas Muscle Weakness as a Key Diagnostic Marker in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

被引:1
|
作者
Matsuura, Eiji [1 ]
Nozuma, Satoshi [1 ]
Dozono, Mika [1 ]
Kodama, Daisuke [2 ]
Tanaka, Masakazu [2 ]
Kubota, Ryuji [2 ]
Takashima, Hiroshi [1 ]
机构
[1] Kagoshima Univ, Dept Neurol & Geriatr, Grad Sch Med & Dent Sci, Kagoshima 8908520, Japan
[2] Kagoshima Univ, Joint Res Ctr Human Retrovirus Infect, Div Neuroimmunol, Kagoshima 8908520, Japan
来源
PATHOGENS | 2023年 / 12卷 / 04期
关键词
HAM; TSP; muscle weakness; muscle involvement; myopathic feature; HTLV-1; I-ASSOCIATED MYELOPATHY; VIRUS-TYPE-I; INCLUSION-BODY MYOSITIS; CLINICAL-FEATURES; SKELETAL-MUSCLE; NATURAL-HISTORY; HTLV-1; POLYMYOSITIS; INVOLVEMENT; INFECTION;
D O I
10.3390/pathogens12040592
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human T-cell leukemia virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a slowly progressive neurological disease that arises from HTLV-1 infection. Pathologically, the condition is characterized by diffuse myelitis, which is most evident in the thoracic spinal cord. Clinical manifestations of the infectious disease, HAM/TSP, are empirically known to include weakness of the proximal muscles of the lower extremities and atrophy of the paraspinal muscles, which is characteristic of the distribution of disturbed muscles usually seen in muscular diseases, except that the upper extremities are almost normal. This unique clinical presentation is useful information for physicians and physical therapists involved in diagnosing and rehabilitating patients with HAM/TSP, as well as critical information for understanding the pathogenesis of HAM/TSP. However, the precise pattern of muscle involvement in this condition has yet to be reported. The purpose of this study was to identify the muscles affected by HAM/TSP in order to understand the pathogenesis of HAM/TSP as well as to aid in the diagnosis and rehabilitation of HAM/TSP. A retrospective review of medical records was conducted on 101 consecutively admitted patients with HAM/TSP at Kagoshima University Hospital. Among 101 patients with HAM/TSP, all but three had muscle weakness in the lower extremities. Specifically, the hamstrings and iliopsoas muscle were the most frequently affected in over 90% of the patients. Manual muscle testing (MMT) revealed that the iliopsoas was the weakest of the muscles assessed, a consistent feature from the early to advanced stages of the disease. Our findings demonstrate a unique distribution of muscle weakness in HAM/TSP, with the proximal muscles of the lower extremities, particularly the iliopsoas muscle, being the most frequently and severely affected.
引用
收藏
页数:9
相关论文
共 50 条
  • [21] SKELETAL-MUSCLE INVOLVEMENT IN TROPICAL SPASTIC PARAPARESIS HTLV-1-ASSOCIATED MYELOPATHY
    GABBAI, AA
    WILEY, CA
    OLIVEIRA, ASB
    SMITH, R
    SCHMIDT, B
    NOBREGA, JAM
    BORDIN, JO
    ROMAN, GC
    MUSCLE & NERVE, 1994, 17 (08) : 923 - 930
  • [22] Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis
    Nozuma, Satoshi
    Matsuura, Eiji
    Matsuzaki, Toshio
    Watanabe, Osamu
    Kubota, Ryuji
    Izumo, Shuji
    Takashima, Hiroshi
    PLOS ONE, 2014, 9 (05):
  • [23] Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
    Taraneh Rajaei
    Hamid Farajifard
    Houshang Rafatpanah
    Reza Bustani
    Narges Valizadeh
    Bahareh Rajaei
    Seyed Abdolrahim Rezaee
    Medical Microbiology and Immunology, 2017, 206 : 195 - 201
  • [24] Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
    Rajaei, Taraneh
    Farajifard, Hamid
    Rafatpanah, Houshang
    Bustani, Reza
    Valizadeh, Narges
    Rajaei, Bahareh
    Rezaee, Seyed Abdolrahim
    MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 2017, 206 (03) : 195 - 201
  • [25] Putative role of HLA polymorphism among a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population
    Schor, Doris
    Porto, Luis Cristovao
    Roma, Eric Henrique
    Castro-Alves, Julio
    Villela, Anna Paula
    Araujo, Abelardo Q. C.
    Gloria Bonecini-Almeida, Maria
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [26] Decrease in naive T cell production due to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) development
    Nunes Gomes, Jessica Antonia
    da Silva Dias, George Alberto
    Fujihara, Satomi
    Yoshikawa, Gilberto Toshimitsu
    Lopes Koyama, Roberta Vilela
    Medeiros Sousa, Rita Catarina
    Simoes Quaresma, Juarez Antonio
    Fuzii, Hellen Thais
    IMMUNOBIOLOGY, 2021, 226 (01)
  • [27] Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis
    Taniguchi, Akitoshi
    Mochizuki, Hitoshi
    Nagamachi, Shigeki
    Ebihara, Yuka
    Ishii, Nobuyuki
    Shiomi, Kazutaka
    Nakazato, Masamitsu
    NEUROLOGICAL SCIENCES, 2015, 36 (11) : 2117 - 2120
  • [28] An insight to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high-throughput data integration and meta-analysis
    Mozhgani, Sayed-Hamidreza
    Piran, Mehran
    Zarei-Ghobadi, Mohadeseh
    Jafari, Mohieddin
    Jazayeri, Seyed-Mohammad
    Mokhtari-Azad, Talat
    Teymoori-Rad, Majid
    Valizadeh, Narges
    Farajifard, Hamid
    Mirzaie, Mehdi
    Khamseh, Azam
    Rafatpanah, Houshang
    Rezaee, Seyed-Abdolrahim
    Norouzi, Mehdi
    RETROVIROLOGY, 2019, 16 (01)
  • [29] Plasma proteome analysis in HTLV-1-associated myelopathy/tropical spastic paraparesis
    Kirk, Paul D. W.
    Witkover, Aviva
    Courtney, Alan
    Lewin, Alexandra M.
    Wait, Robin
    Stumpf, Michael P. H.
    Richardson, Sylvia
    Taylor, Graham P.
    Bangham, Charles R. M.
    RETROVIROLOGY, 2011, 8 : 81
  • [30] Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
    Saeidi, Morteza
    Sasannejad, Payam
    Foroughipour, Mohsen
    Shahami, SaeedReza
    Shoeibi, Ali
    ACTA NEUROLOGICA BELGICA, 2011, 111 (01) : 41 - 44