Iliopsoas Muscle Weakness as a Key Diagnostic Marker in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

被引:1
|
作者
Matsuura, Eiji [1 ]
Nozuma, Satoshi [1 ]
Dozono, Mika [1 ]
Kodama, Daisuke [2 ]
Tanaka, Masakazu [2 ]
Kubota, Ryuji [2 ]
Takashima, Hiroshi [1 ]
机构
[1] Kagoshima Univ, Dept Neurol & Geriatr, Grad Sch Med & Dent Sci, Kagoshima 8908520, Japan
[2] Kagoshima Univ, Joint Res Ctr Human Retrovirus Infect, Div Neuroimmunol, Kagoshima 8908520, Japan
来源
PATHOGENS | 2023年 / 12卷 / 04期
关键词
HAM; TSP; muscle weakness; muscle involvement; myopathic feature; HTLV-1; I-ASSOCIATED MYELOPATHY; VIRUS-TYPE-I; INCLUSION-BODY MYOSITIS; CLINICAL-FEATURES; SKELETAL-MUSCLE; NATURAL-HISTORY; HTLV-1; POLYMYOSITIS; INVOLVEMENT; INFECTION;
D O I
10.3390/pathogens12040592
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human T-cell leukemia virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a slowly progressive neurological disease that arises from HTLV-1 infection. Pathologically, the condition is characterized by diffuse myelitis, which is most evident in the thoracic spinal cord. Clinical manifestations of the infectious disease, HAM/TSP, are empirically known to include weakness of the proximal muscles of the lower extremities and atrophy of the paraspinal muscles, which is characteristic of the distribution of disturbed muscles usually seen in muscular diseases, except that the upper extremities are almost normal. This unique clinical presentation is useful information for physicians and physical therapists involved in diagnosing and rehabilitating patients with HAM/TSP, as well as critical information for understanding the pathogenesis of HAM/TSP. However, the precise pattern of muscle involvement in this condition has yet to be reported. The purpose of this study was to identify the muscles affected by HAM/TSP in order to understand the pathogenesis of HAM/TSP as well as to aid in the diagnosis and rehabilitation of HAM/TSP. A retrospective review of medical records was conducted on 101 consecutively admitted patients with HAM/TSP at Kagoshima University Hospital. Among 101 patients with HAM/TSP, all but three had muscle weakness in the lower extremities. Specifically, the hamstrings and iliopsoas muscle were the most frequently affected in over 90% of the patients. Manual muscle testing (MMT) revealed that the iliopsoas was the weakest of the muscles assessed, a consistent feature from the early to advanced stages of the disease. Our findings demonstrate a unique distribution of muscle weakness in HAM/TSP, with the proximal muscles of the lower extremities, particularly the iliopsoas muscle, being the most frequently and severely affected.
引用
收藏
页数:9
相关论文
共 50 条
  • [1] Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
    Enose-Akahata, Yoshimi
    Jacobson, Steven
    RETROVIROLOGY, 2019, 16 (01)
  • [2] Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
    Yoshimi Enose-Akahata
    Steven Jacobson
    Retrovirology, 16
  • [3] Real-world clinical course of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Japan
    Tsutsumi, Shuntaro
    Sato, Tomoo
    Yagishita, Naoko
    Yamauchi, Junji
    Araya, Natsumi
    Hasegawa, Daisuke
    Nagasaka, Misako
    Coler-Reilly, Ariella L. G.
    Inoue, Eisuke
    Takata, Ayako
    Yamano, Yoshihisa
    ORPHANET JOURNAL OF RARE DISEASES, 2019, 14 (01)
  • [4] Neuropathology of HTLV-1-associated myelopathy (HAM/TSP)
    Izumo, Shuji
    NEUROPATHOLOGY, 2010, 30 (05) : 480 - 485
  • [5] Curcumin increased the expression of c-FLIP in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients
    Poursina, Zohreh
    Mohammadi, Asadollah
    Yazdi, Shadi Zamanian
    Humpson, Ian
    Vakili, Veda
    Boostani, Reza
    Rafatpanah, Houshang
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (09) : 15740 - 15745
  • [6] Chitotriosidase 1 in the cerebrospinal fluid as a putative biomarker for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) progression
    Pinheiro Gomes, Yago Cortes
    Freitas, Nicole Lardini
    Souza, Flavia Santos
    Sandim, Vanessa
    Pereira, Denise Abreu
    Sousa Nogueira, Fabio Cesar
    Echevarria-Lima, Juliana
    Celestino Bezerra Leite, Ana Claudia
    Sales Dantas Lima, Marco Antonio
    Teixeira Silva, Marcus Tulius
    Campos Araujo, Abelardo Queiroz
    Paulo Vicente, Ana Carolina
    Espindola, Otavio Melo
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [7] Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran
    Shoeibi, Ali
    Rafatpanah, Houshang
    Azarpazhooh, Amir
    Mokhber, Naghme
    Hedayati-Moghaddam, Mohammad Reza
    Amiri, Amin
    Hashemi, Peyman
    Foroghipour, Mohsen
    Hoseini, Reza Farid
    Bazarbachi, Ali
    Azarpazhooh, Mahmoud Reza
    ACTA NEUROLOGICA BELGICA, 2013, 113 (04) : 427 - 433
  • [8] Pregnancy complicated by HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP): a case report
    Mori, Hiroshi
    Shibata, Eiji
    Kuwazuru, Tomoichiro
    Uchimura, Takayuki
    Kondo, Emi
    Iwanaka, Yukio
    Yoshino, Kiyoshi
    CLINICAL CASE REPORTS, 2021, 9 (07):
  • [9] Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran
    Ali Shoeibi
    Houshang Rafatpanah
    Amir Azarpazhooh
    Naghme Mokhber
    Mohammad Reza Hedayati-Moghaddam
    Amin Amiri
    Peyman Hashemi
    Mohsen Foroghipour
    Reza Farid Hoseini
    Ali Bazarbachi
    Mahmoud Reza Azarpazhooh
    Acta Neurologica Belgica, 2013, 113 : 427 - 433
  • [10] Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)
    Baratella, Marco
    Forlani, Greta
    Raval, Goutham U.
    Tedeschi, Alessandra
    Gout, Olivier
    Gessain, Antoine
    Tosi, Giovanna
    Accolla, Roberto S.
    PLOS NEGLECTED TROPICAL DISEASES, 2017, 11 (01):