Glutathione for Food and Health Applications with Emphasis on Extraction, Identification, and Quantification Methods: A Review

被引:26
作者
Al-Temimi, Anfal Alwan [1 ]
Al-Mossawi, Aum-El-Bashar [1 ]
Al-Hilifi, Sawsan A. [1 ]
Korma, Sameh A. [2 ,3 ]
Esatbeyoglu, Tuba [4 ]
Rocha, Joao Miguel [5 ]
Agarwal, Vipul [6 ]
机构
[1] Univ Basrah, Coll Agr, Dept Food Sci, Basrah 61014, Iraq
[2] Zagazig Univ, Fac Agr, Dept Food Sci, Zagazig 44519, Egypt
[3] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510641, Peoples R China
[4] Leibniz Univ Hannover, Inst Food Sci & Human Nutr, Dept Food Dev & Food Qual, Kleinen Felde 30, D-30167 Hannover, Germany
[5] Univ Catolica Portuguesa, CBQF Ctr Biotecnol & Quim Fina, Lab Associado, Escola Super Biotecnol, Rua Diogo Botelho 1327, P-4169005 Porto, Portugal
[6] Univ New South Wales, Sch Chem Engn, Cluster Adv Macromol Design CAMD, Sydney, NSW 2052, Australia
基金
英国医学研究理事会;
关键词
glutathione; oxidative stress; bioactive peptides; natural peptide; LIQUID-CHROMATOGRAPHY; OXIDIZED GLUTATHIONE; OXIDATIVE STRESS; TOLERANCE; FORM; METABOLISM; MECHANISMS; ASCORBATE; RESPONSES; DEFENSE;
D O I
10.3390/metabo13040465
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glutathione is a naturally occurring compound that plays a crucial role in the cellular response to oxidative stress through its ability to quench free radicals, thus mitigating the risk of potential damage, including cell death. While glutathione is endogenously present in different plants and animal cells, their concentration varies considerably. The alteration in glutathione homeostasis can be used as a potential marker for human diseases. In the case of the depletion of endogenous glutathione, exogenous sources can be used to replenish the pool. To this end, both natural and synthetic glutathione can be used. However, the health benefit of glutathione from natural sources derived from fruits and vegetables is still debated. There is increasingly growing evidence of the potential health benefits of glutathione in different diseases; however, the determination and in situ quantification of endogenously produced glutathione remains a major challenge. For this reason, it has been difficult to understand the bioprocessing of exogenously delivered glutathione in vivo. The development of an in situ technique will also aid in the routine monitoring of glutathione as a biomarker for different oxidative stress-mediated diseases. Furthermore, an understanding of the in vivo bioprocessing of exogenously delivered glutathione will also aid the food industry both towards improving the longevity and profile of food products and the development of glutathione delivery products for long-term societal health benefits. In this review, we surveyed the natural plant-derived sources of glutathione, the identification and quantification of extracted glutathione from these sources, and the role of glutathione in the food industry and its effect on human health.
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页数:18
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