Review on two-dimensional material-based field-effect transistor biosensors: accomplishments, mechanisms, and perspectives

被引：26

作者：

Chen, Shuo ^{[1
]}

Sun, Yang ^{[2
]}

Fan, Xiangyu ^{[1
]}

Xu, Yazhe ^{[1
]}

Chen, Shanshan ^{[1
]}

Zhang, Xinhao ^{[1
]}

Man, Baoyuan ^{[1
]}

Yang, Cheng ^{[1
]}

Du, Jun ^{[1
]}

机构：

[1] Shandong Normal Univ, Sch Phys & Elect, Jinan 250014, Peoples R China

[2] Univ Sci & Technol, Sch Chem & Biol Engn, Beijing Key Lab Bioengn & Sensing Technol, 30 Xueyuan Rd, Beijing 100083, Peoples R China

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2023年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Two-Dimensional Material; Field-effect transistor; Biosensor; Biomarker detection; Sensing application; LABEL-FREE DETECTION; GATED GRAPHENE TRANSISTORS; DNA HYBRIDIZATION; ULTRASENSITIVE DETECTION; ELECTRICAL DETECTION; SELECTIVE DETECTION; INFLUENZA-VIRUS; SINGLE; OXIDE; SENSITIVITY;

D O I：

10.1186/s12951-023-01898-z

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Field-effect transistor (FET) is regarded as the most promising candidate for the next-generation biosensor, benefiting from the advantages of label-free, easy operation, low cost, easy integration, and direct detection of biomarkers in liquid environments. With the burgeoning advances in nanotechnology and biotechnology, researchers are trying to improve the sensitivity of FET biosensors and broaden their application scenarios from multiple strategies. In order to enable researchers to understand and apply FET biosensors deeply, focusing on the multidisciplinary technical details, the iteration and evolution of FET biosensors are reviewed from exploring the sensing mechanism in detecting biomolecules (research direction 1), the response signal type (research direction 2), the sensing performance optimization (research direction 3), and the integration strategy (research direction 4). Aiming at each research direction, forward perspectives and dialectical evaluations are summarized to enlighten rewarding investigations.

引用

页数：32

共 211 条

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