Gene-environment interactions and their impact on human health

被引:79
作者
Virolainen, Samuel J. [1 ,2 ]
VonHandorf, Andrew [1 ]
Viel, Kenyatta C. M. F. [1 ]
Weirauch, Matthew T. [1 ,2 ,3 ,4 ]
Kottyan, Leah C. [1 ,2 ,4 ,5 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Ctr Autoimmune Genom & Etiol, Div Human Genet, 3333 Burnet Ave, Cincinnati, OH 45229 USA
[2] Univ Cincinnati, Immunol Grad Program, Coll Med, 3230 Eden Ave, Cincinnati, OH 45229 USA
[3] Cincinnati Childrens Hosp Med Ctr, Div Biomed Informat & Dev Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA
[4] Univ Cincinnati, Dept Pediat, Coll Med, 3230 Eden Ave, Cincinnati, OH 45229 USA
[5] Cincinnati Childrens Hosp Med Ctr, Div Allergy & Immunol, 3333 Burnet Ave,MLC 15012, Cincinnati, OH 45229 USA
基金
美国国家卫生研究院;
关键词
EPSTEIN-BARR-VIRUS; INFLAMMATORY-BOWEL-DISEASE; SEX-CHROMOSOME COMPLEMENT; VIRAL-INFECTIONS; CLIMATE-CHANGE; HUMAN-PAPILLOMAVIRUS; HYGIENE HYPOTHESIS; ALLERGIC DISEASES; TOXIC METALS; FOLLOW-UP;
D O I
10.1038/s41435-022-00192-6
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The molecular processes underlying human health and disease are highly complex. Often, genetic and environmental factors contribute to a given disease or phenotype in a non-additive manner, yielding a gene-environment (G x E) interaction. In this work, we broadly review current knowledge on the impact of gene-environment interactions on human health. We first explain the independent impact of genetic variation and the environment. We next detail well-established G x E interactions that impact human health involving environmental toxicants, pollution, viruses, and sex chromosome composition. We conclude with possibilities and challenges for studying G x E interactions.
引用
收藏
页码:1 / 11
页数:11
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