Peptide-Mediated Nanocarriers for Targeted Drug Delivery: Developments and Strategies

被引：4
作者：
Wang, Yubo [1 ]
Zhang, Lu [2 ,3 ]
Liu, Chen [3 ]
Luo, Yiming [4 ,5 ,6 ]
Chen, Dengyue [3 ]
机构：
[1] Guangxi Univ, Med Coll, Da Xue Dong Rd 100, Nanning 530004, Peoples R China
[2] Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China
[3] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361005, Peoples R China
[4] Xiamen Univ, Affiliated Hosp 1, Dept Hematol, 55 Zhenhai Rd, Xiamen 361003, Peoples R China
[5] Xiamen Univ, Sch Med, Inst Hematol, 55 Zhenhai Rd, Xiamen 361003, Peoples R China
[6] Fujian Med Univ, Sch Clin Med, Fuzhou 351002, Peoples R China
来源：
PHARMACEUTICS | 2024年 / 16卷 / 02期
基金：
中国国家自然科学基金;
关键词：
peptides; self-assembly; peptide-drug conjugates; drug delivery; peptide modification; CANCER-CELL DEATH; DE-NOVO DESIGN; PENETRATING PEPTIDE; IN-VIVO; ANTICANCER ACTIVITY; ANTITUMOR-ACTIVITY; SENSITIVE LIPOSOMES; ENHANCED STABILITY; CONTROLLED-RELEASE; CLEAVABLE PEG;
D O I：
10.3390/pharmaceutics16020240
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effective drug delivery is essential for cancer treatment. Drug delivery systems, which can be tailored to targeted transport and integrated tumor therapy, are vital in improving the efficiency of cancer treatment. Peptides play a significant role in various biological and physiological functions and offer high design flexibility, excellent biocompatibility, adjustable morphology, and biodegradability, making them promising candidates for drug delivery. This paper reviews peptide-mediated drug delivery systems, focusing on self-assembled peptides and peptide-drug conjugates. It discusses the mechanisms and structural control of self-assembled peptides, the varieties and roles of peptide-drug conjugates, and strategies to augment peptide stability. The review concludes by addressing challenges and future directions.
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页数：32
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