Infectious Inequity: How the Gut Microbiome and Social Determinants of Health May Contribute to Clostridioides difficile Infection Among Racial and Ethnic Minorities

被引:2
作者
Reveles, Kelly R. [1 ,2 ,6 ]
Strey, Kelsey A. [1 ,2 ]
Abdul-Mutakabbir, Jacinda C. [3 ,4 ]
Mendoza, V. Mateo [1 ,2 ]
Carreno, Joseph J. [5 ,7 ]
机构
[1] Univ Texas Austin, Coll Pharm, Pharmacotherapy Div, Austin, TX USA
[2] Univ Texas Hlth San Antonio, Pharmacotherapy Educ & Res Ctr, San Antonio, TX USA
[3] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, Div Clin Pharm, La Jolla, CA USA
[4] Univ Calif San Diego, Div Black Diaspora & African Amer Studies, Div Clin Pharm, La Jolla, CA USA
[5] Albany Coll Pharm & Hlth Sci, Dept Pharm Practice, Albany, NY USA
[6] UT Hlth San Antonio, Pharmacotherapy Educ & Res Ctr, 7703 Floyd Curl,MSC 6220, San Antonio, TX 78229 USA
[7] Albany Coll Pharm & Hlth Sci, Dept Pharm Practice, 106 New Scotland Ave, Albany, NY 12208 USA
基金
美国国家卫生研究院;
关键词
Clostridioides difficile; microbiome; health disparities; social determinants of health; infectious diseases; UNITED-STATES; DISPARITIES; DYSBIOSIS; RISK; ASSOCIATION; COMMUNITY; DISEASES;
D O I
10.1093/cid/ciad586
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Infectious diseases are a leading contributor to death in the United States, and racial differences in clinical outcomes have been increasingly reported. Clostridioides difficile infection (CDI) is a growing public health concern, as it causes nearly half a million infections per year and considerable excess hospital costs. Concurrent with other infectious diseases, recent literature denotes racial disparities in CDI incidence rates, mortality, and associated morbidity. Of note, investigations into CDI and causative factors suggest that inequities in health-related social needs and other social determinants of health (SDoH) may cause disruption to the gut microbiome, thereby contributing to the observed deleterious outcomes in racially and ethnically minoritized individuals. Despite these discoveries, there is limited literature that provides context for the recognized racial disparities in CDI, particularly the influence of structural and systemic barriers. Here, we synthesize the available literature describing racial inequities in CDI outcomes and discuss the interrelationship of SDoH on microbiome dysregulation. Finally, we provide actionable considerations for infectious diseases professionals to aid in narrowing CDI equity gaps.
引用
收藏
页码:S455 / S462
页数:8
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