Effects of exposure to nano-plastic drinking during pregnancy on cognitive related proteins in offspring of SD rats

被引：6
作者：
Chen, Jiang [1 ,2 ]
Zhang, Yaping [2 ]
Liu, Xuan [2 ]
Li, Kang [2 ]
Liu, Huanliang [2 ]
Lai, Wenqing [2 ]
Shi, Yue [2 ]
Xi, Zhuge [2 ]
Yan, Licheng [1 ]
Tian, Lei [2 ]
Lin, Bencheng [2 ]
机构：
[1] North China Univ Sci & Technol, Sch Publ Hlth, Tangshan, Peoples R China
[2] Tianjin Inst Environm & Operat Med, Tianjin, Peoples R China
来源：
ENVIRONMENTAL POLLUTANTS AND BIOAVAILABILITY | 2024年 / 36卷 / 01期
关键词：
Nanopolystyrene; proteomic analysis; transgenerational neurotoxicity; hippocampal; FERROPTOSIS; BRAIN;
D O I：
10.1080/26395940.2023.2292104
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nanoplastics, an emerging contaminant, pose risks to fetal neural development, transferring from mother to offspring via placenta and breast milk. Assessing these risks, hippocampal CA3 samples from nanopolystyrene-exposed rat offspring were proteomically analyzed. Findings revealed reduced expression of neural developmental proteins (KIF21A, STMN2, DMTN, DLG1) and increased inhibitory proteins (PZP, alpha-2M, FN1, SERPINA1, ALOX15) in the hippocampus. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis highlighted ferroptosis enrichment, validated by significantly expressed ALOX15 and TF proteins. These alterations suggest nanopolystyrene's potential contribution to cognitive deficits and neurodevelopmental disorders, emphasizing its hazardous impact on neural development. This study provides novel insights into nanopolystyrene's risks.
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页数：11
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