The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma

被引：4
作者：
Yang, Qianqian [1 ]
Tian, Hui [2 ]
Guo, Ziyi [1 ]
Ma, Zhongliang [1 ]
Wang, Guangzhi [3 ,4 ]
机构：
[1] Shanghai Univ, Sch Life Sci, Lab Noncoding RNA & Canc, Shanghai 200444, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Dept Geriatr, Shanghai 200032, Peoples R China
[3] Weifang Med Univ, Sch Med Imaging, Weifang 261053, Peoples R China
[4] Weifang Med Univ, Dept Med Imaging Ctr, Affiliated Hosp, Weifang 261053, Peoples R China
来源：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2023年 / 55卷 / 11期
关键词：
noncoding RNAs; HIF-1; alpha; hepatocellular carcinoma; tumor microenvironment; HYPOXIA-INDUCIBLE FACTORS; CANCER; ANGIOGENESIS; PROGRESSION; MICRORNAS; PROMOTES; CELLS; PROLIFERATION; HIF-1-ALPHA; METASTASIS;
D O I：
10.3724/abbs.2023231
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hepatocellular carcinoma (HCC) is the leading fatal malignancy worldwide. The tumor microenvironment (TME) can affect the survival, proliferation, migration, and even dormancy of cancer cells. Hypoxia is an important component of the TME, and hypoxia-inducible factor-1 alpha (HIF-1 alpha) is the most important transcriptional regulator. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), comprise a large part of the human transcriptome and play an important role in regulating the tumorigenesis of HCC. This review discusses the role of ncRNAs in hepatocarcinogenesis, epithelial-mesenchymal transition (EMT), and angiogenesis in a hypoxic microenvironment, as well as the interactions between ncRNAs and key components of the TME. It further discusses their use as biomarkers and the potential clinical value of drugs, as well as the challenges faced in the future.
引用
收藏
页码：1697 / 1706
页数：10
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