Antioxidative and neuroprotective potential of Acorus calamus linn. and Cordia dichotoma G. Forst. In Alzheimer's type dementia in rodent

被引：5

作者：

Malik, Rohit ^{[1
,2
]}

Kalra, Sunishtha ^{[1
]}

Pooja ^{[3
]}

Singh, Govind ^{[1
]}

Meenu ^{[1
]}

Gahlot, Vinod ^{[4
]}

Kajal, Anjali ^{[5
]}

Rimpy ^{[6
]}

机构：

[1] Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak, Haryana, India

[2] Gurugram Global Coll Pharm, Gurugram, India

[3] Cent Univ Haryana, Dept Pharmaceut Sci, Mahendergarh, Haryana, India

[4] HIMT Coll Pharm, Knowledge Pk 1, Greater Noida 201310, Uttar Pradesh, India

[5] Baba Mastnath Univ, Rohtak, Haryana, India

[6] Shandong First Med Univ, Jinan, Peoples R China

来源：

BRAIN RESEARCH | 2024年 / 1822卷

关键词：

Acorus calamus; Alzheimer's disease; Cordia dichotoma; Dementia; Scopolamine; Neurodegeneration; ESSENTIAL OIL; SCOPOLAMINE; MEMORY;

D O I：

10.1016/j.brainres.2023.148616

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The goal of this research study was to see how plant extracts of Acorus calamus Linn. and Cordia dichotoma G. Forst. overcome scopolamine-induced Alzheimer's type dementia in mice by activating the cholinergic system, anti-oxidant and protection of neuronal death in the brain (hippocampus region). Scopolamine (1 mg/kg i.p.) reduced mice's routine in behavioral parameters such as Morris Water Maze (MWM), Elevated Plus Maze (EPM), and also the locomotor activity. It also decreases antioxidant levels such as Reduced glutathione (GSH) and also Superoxide dismutase (SOD) but also increases the level of Acetylcholinesterase enzyme (AChE) in brain. Assessment of various behavioral, and biochemical parameters (AChE, SOD, GSH, and Nitrite level) were compared with each group. Acorus calamus (hydro-alcoholic 1:1) 600 mg/kg p.o. and the combination (Acorus calamus 600 mg/kg p.o. + Cordia dichotoma 750 mg/kg p.o.) group showed significant results as compared to Cordia dichotoma 750 mg/kg p.o.in behavioral as well as in biochemical parameters. Histological studies showed significant neuroprotection in the Acorus calamus-treated group and the combination-treated groups. In the future, the Acorus calamus and the combination are possibly helpful in the treatment of various cognitive disorders or it may be valuable to investigate the pharmacological potential of such plant extracts during the treatment of neurodegenerative disorders.

引用

页数：10

共 30 条

[1] The Effects of Inhaled Pimpinella peregrina Essential Oil on Scopolamine-Induced Memory Impairment, Anxiety, and Depression in Laboratory Rats [J].