Using cross laminated timber (CLT) floor panels in combination with steel framing has been identified as a promising new structural configuration that can reduce the embodied greenhouse gas emissions of buildings. This project evaluated efficient structural design of hybrid steel-timber floor sections for a wide range of design parameters to determine the reductions in global warming potential possible relative to a conventional steel -concrete cross section. Each of the structural designs was checked for strength limit states, deflection, and minimum fire rating of either unrated, 1-h, or 2-h for a range of deck spans between 2.3 m and 4.6 m and beam spans between 5.5 m and 13.5 m. For an unrated floor assembly there is little global warming potential benefit to use steel-timber floors if a topping slab is included on top of the CLT slab. Whereas, using steel-timber configura-tions without a topping slab result in the largest global warming potential reductions. For the 1-h and 2-h ratings, even steel-timber configurations with a 64 mm thick topping slab had up to 20% reduction in global warming potential compared to the steel-concrete alternative. Additionally, sev-eral considerations that can drastically affect the global warming potential results were discussed. The results from this project demonstrate the best practices for structural design of hybrid steel-timber buildings to reduce global warming potential of the superstructure frame by between 5% and 35% relative to conventional steel and concrete construction.