Activatable organic upconversion nanoprobe for bioimaging of monoamine oxidase B in Parkinson's disease

被引：3
作者：
Zhang, Yuanyuan [1 ,3 ]
Wang, Jing [3 ]
Yi, Wanxiang [3 ]
Tiemuer, Aliya [3 ]
Yu, Hui [3 ]
Liu, Yi [2 ,3 ]
Su, Dan [1 ]
机构：
[1] Hangzhou Med Coll, Dept Clin Med, Key Lab Drug Safety Evaluat & Res Zhejiang Prov, Hangzhou 310053, Peoples R China
[2] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Jiangsu Key Lab Biosensors, 9 Wenyuan Rd, Nanjing 210023, Peoples R China
[3] China Pharmaceut Univ, Sch Engn, Nanjing 211198, Peoples R China
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2023年 / 389卷
基金：
中国国家自然科学基金;
关键词：
Frequency upconversion luminescence; Monoamine oxidase B; Near Infrared nanoprobes; Bio-imaging; Parkinson's disease; FLUORESCENT-PROBE; MAO-A; MICE; DESIGN;
D O I：
10.1016/j.snb.2023.133880
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Monoamine oxidase B (MAO-B) activity has been observed abnormally elevated in Parkinson's disease patients and can be used as a potential biomarker. Herein, we report an activatable frequency upconversion luminescence (FUCL) MAO-B nano-probe (NIR-MNP) capable of highly specific and real-time MAO-B imaging in biological samples. The turn-on FUCL effect is beneficial to obtaining high-quality imaging and penetrating tissue to achieve in vivo imaging, making it stand out from the existing probes. Moreover, we used NIR-MNP to confirm the role of MAO-B inhibitor in delaying Parkinson's disease (PD) progression in mouse PD models through bioimaging technique in vivo. Finally, our study may offer a visual way help researchers to gain further insight into the involvement of MAO-B in PD onset and progression in animals.
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页数：9
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