Crossing the Non-Human Primate Blood Brain Barrier with Machine-Guided AAV Capsid Design

被引：0
|
作者：
Bailey, Megan Elizabeth [1 ]
Bloodgood, Dan [1 ]
Chen, Ina [1 ]
Gerold, Jeff [1 ]
Holth, Jerrah [1 ]
Jajoo, Rishi [1 ]
Kelsic, Eric [1 ]
Lin, Kathy S. [1 ]
McDonel, Patrick [1 ]
Vihani, Aashu [1 ]
Wolock, Sam [1 ]
机构：
[1] Dyno Therapeut, Watertown, MA USA
来源：
MOLECULAR THERAPY | 2023年 / 31卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
382
引用
收藏
页码：204 / 204
页数：1
相关论文
共 50 条
  • [21] Antibody-Based AAV Retargeting to Transferrin Receptor Mediates Efficient Blood Brain Barrier Crossing and In Vivo Gene Delivery to the CNS in Mice and Non-Human Primates
    Nambiar, Kalyani
    Plasterer, Kyle
    Tareen, Ammar
    Aime-Wilson, Pascaline
    Keating, Nicole
    Galligan, Caryn
    Dugan, John
    Ishmam, Tazeen
    LoMastro, Anthony
    Gao, Min
    Shevade, Aishwarya
    Zhang, Zhe
    Mink, Sheldon
    Tustian, Andrew David
    Macdonald, Lynn
    Kyratsous, Christos
    Sabin, Leah
    MOLECULAR THERAPY, 2024, 32 (04) : 64 - 64
  • [22] Gene Delivery to Non-Human Primate Embryos Using AAV Vectors
    Wang, Dan
    Niu, Yuyu
    Ren, Lingzhi
    Tai, Phillip W. L.
    Ji, Weizhi
    Gao, Guangping
    MOLECULAR THERAPY, 2019, 27 (04) : 110 - 110
  • [23] A Multiplexed Barcode Approach to Simultaneously Evaluate Gene Delivery by AAV Capsid Variants Across Multiple Non-Human Primate Tissues
    Stone, Daniel
    Meumann, Nadja
    Kuhlmann, Anne-Sophie
    Peterson, Christopher W.
    Xie, Hong
    Roychoudhury, Pavitra
    Loprieno, Michelle A.
    Xuan-Khang, Vu
    Strongin, Daniel
    Kenkel, Elizabeth
    Haick, Anoria
    Stensland, Laurence
    Obenza, Willimark
    Parrott, Jacob
    Nelson, Veronica
    Murnane, Robert
    Huang, Meei-Li
    Aubert, Martine
    Kiem, Hans-Peter
    Buning, Hildegard
    Jerome, Keith R.
    MOLECULAR THERAPY, 2023, 31 (04) : 205 - 205
  • [24] Trophism of AAV2 and AAV5 vectors in the non-human primate retina
    Lotery, AJ
    Derksen, TA
    Russell, SR
    Mullins, RF
    Yang, GS
    Kopp, KK
    Eastman, CG
    Stone, EM
    Davidson, BL
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2002, 43 : U1308 - U1308
  • [25] Machine-Guided Design Reveals AAV Variants Efficient in Transducing NHP Retina After Intravitreal Delivery
    Turunen, Heikki T.
    Cramer, Megan
    Gerold, Jeff
    Kuchwara, Helene
    Kwasnieski, Jamie C.
    Lapan, Sylvain
    Lin, Kathy
    Locane, Elina
    Marrogi, Eryney
    McDonel, Patrick
    Levitin, Hanna Mendes
    Nagabhushana, Nishith
    Otwinowski, Jakub
    Reardon, Christopher
    Sengel, Cem
    Sinai, Sam
    Wolock, Sam
    Kelsic, Eric
    MOLECULAR THERAPY, 2022, 30 (04) : 555 - 555
  • [26] Glucocerebrosidase expression patterns in the non-human primate brain
    Dopeso-Reyes, Iria G.
    Sucunza, Diego
    Rico, Alberto J.
    Pignataro, Diego
    Marin-Ramos, David
    Roda, Elvira
    Rodriguez-Perez, Ana I.
    Labandeira-Garcia, Jose L.
    Lanciego, Jose L.
    BRAIN STRUCTURE & FUNCTION, 2018, 223 (01): : 343 - 355
  • [27] Causal Network in a Deafferented Non-human Primate Brain
    Balasubramanian, Karthikeyan
    Takahashi, Kazutaka
    Hatsopoulos, Nicholas G.
    2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2015, : 59 - 62
  • [28] Glucocerebrosidase expression patterns in the non-human primate brain
    Iria G. Dopeso-Reyes
    Diego Sucunza
    Alberto J. Rico
    Diego Pignataro
    David Marín-Ramos
    Elvira Roda
    Ana I. Rodríguez-Pérez
    José L. Labandeira-García
    José L. Lanciego
    Brain Structure and Function, 2018, 223 : 343 - 355
  • [29] Distribution of norepinephrine transporters in the non-human primate brain
    Smith, HR
    Beveridge, TJR
    Porrino, LJ
    NEUROSCIENCE, 2006, 138 (02) : 703 - 714
  • [30] Non-human primate models of neonatal brain injury
    Inder, T
    Neil, J
    Yoder, B
    Rees, S
    SEMINARS IN PERINATOLOGY, 2004, 28 (06) : 396 - 404
12345