Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States

被引：53

作者：

Feng, Aijing ^{[1
,2
,3
]}

Bevins, Sarah ^{[4
]}

Chandler, Jeff ^{[5
]}

DeLiberto, Thomas J. ^{[6
]}

Ghai, Ria ^{[7
]}

Lantz, Kristina ^{[8
]}

Lenoch, Julianna ^{[4
]}

Retchless, Adam ^{[9
]}

Shriner, Susan ^{[5
]}

Tang, Cynthia Y. ^{[1
,3
,10
]}

Tong, Suxiang Sue ^{[9
]}

Torchetti, Mia ^{[8
]}

Uehara, Anna ^{[9
]}

Wan, Xiu-Feng ^{[1
,2
,3
,10
,11
]}

机构：

[1] Univ Missouri, Ctr Influenza & Emerging Infect Dis, Columbia, MO 65211 USA

[2] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65211 USA

[3] Univ Missouri, Bond Life Sci Ctr, Columbia, MO 65211 USA

[4] USDA, APHIS Wildlife Serv Natl Wildlife Dis Program, Ft Collins, CO USA

[5] USDA, Natl Wildlife Res Ctr, Wildlife Serv, Anim & Plant Hlth Inspection Serv, Ft Collins, CO USA

[6] USDA, APHIS Wildlife Serv, Ft Collins, CO 80524 USA

[7] CDCP, Natl Ctr Emerging & Zoonot Infect Dis, One Hlth Off, Atlanta, GA USA

[8] USDA, Natl Vet Serv Labs, Anim & Plant Hlth Inspection Serv, Ames, IA USA

[9] CDCP, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

[10] Univ Missouri, MU Inst Data Sci & Informat, Columbia, MO 65211 USA

[11] Univ Missouri, Coll Engn, Dept Elect Engn & Comp Sci, Columbia, MO 65211 USA

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

基金：

美国国家卫生研究院;

关键词：

INFLUENZA; ACCURACY; VIRUSES;

D O I：

10.1038/s41467-023-39782-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SARS-CoV-2 is a zoonotic virus with documented bi-directional transmission between people and animals. Transmission of SARS-CoV-2 from humans to free-ranging white-tailed deer (Odocoileus virginianus) poses a unique public health risk due to the potential for reservoir establishment where variants may persist and evolve. We collected 8,830 respiratory samples from free-ranging white-tailed deer across Washington, D.C. and 26 states in the United States between November 2021 and April 2022. We obtained 391 sequences and identified 34 Pango lineages including the Alpha, Gamma, Delta, and Omicron variants. Evolutionary analyses showed these white-tailed deer viruses originated from at least 109 independent spillovers from humans, which resulted in 39 cases of subsequent local deer-to-deer transmission and three cases of potential spillover from white-tailed deer back to humans. Viruses repeatedly adapted to white-tailed deer with recurring amino acid substitutions across spike and other proteins. Overall, our findings suggest that multiple SARS-CoV-2 lineages were introduced, became enzootic, and co-circulated in white-tailed deer. The SARS-CoV-2 virus has been documented to transmit between humans and animals, providing opportunities for viral reservoirs. Here, the authors show SARS-CoV-2 lineages in free-ranging white-tailed deer across the United States, long after the lineages had declined in human populations.

引用

页数：17

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