Extrafollicular IgD-CD27-CXCR5-CD11c-DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19

被引：25

作者：

Allard-Chamard, Hugues ^{[1
,2
]}

Kaneko, Naoki ^{[1
,3
]}

Bertocchi, Alice ^{[1
]}

Sun, Na ^{[1
]}

Boucau, Julie ^{[1
]}

Kuo, Hsiao-Hsuan ^{[1
]}

Farmer, Jocelyn R. ^{[1
]}

Perugino, Cory ^{[1
,4
]}

Mahajan, Vinay S. ^{[1
]}

Murphy, Samuel J. H. ^{[1
]}

Premo, Katherine ^{[1
]}

Diefenbach, Thomas ^{[1
]}

Ghebremichael, Musie ^{[1
]}

Yuen, Grace ^{[1
]}

Kotta, Alekhya ^{[1
]}

Akman, Zafer ^{[1
]}

Lichterfeld, Mathias ^{[1
,6
]}

Walker, Bruce D. ^{[1
,7
,8
]}

Yu, Xu G. ^{[3
]}

Moriyama, Masafumi ^{[3
]}

Maehara, Takashi ^{[1
,3
]}

Nakamura, Seiji ^{[3
]}

Stone, John H. ^{[4
]}

Padera, Robert F. ^{[5
]}

Pillai, Shiv ^{[1
]}

机构：

[1] MIT & Harvard, Ragon Inst MGH, Cambridge, MA 02139 USA

[2] Univ Sherbrooke, Fac med & Sci Sante, Ctr Rech Clin Etienne Le Bel, Div Rheumatol, Sherbrooke, PQ J1K 2R1, Canada

[3] Kyushu Univ, Fac Dent Sci, Div Maxillofacial Diagnost & Surg Sci, Sect Oral & Maxillofacial Oncol, Fukuoka, Japan

[4] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02114 USA

[5] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[6] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[7] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[8] MIT, Inst Med Engn & Sci, Dept Biol, Cambridge, MA 02139 USA

来源：

CELL REPORTS | 2023年 / 42卷 / 06期

关键词：

B cell depletion in disease; COVID-19; pathogenesis; CP: Immunology; DN3 B cells; double-negative B cells; extrafollicular B cells; IgG4-related disease; inflammatory fibrosis; T-B collaboration in disease;

D O I：

10.1016/j.celrep.2023.112630

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although therapeutic B cell depletion dramatically resolves inflammation in many diseases in which anti-bodies appear not to play a central role, distinct extrafollicular pathogenic B cell subsets that accumulate in disease lesions have hitherto not been identified. The circulating immunoglobulin D (IgD)-CD27- CXCR5-CD11c+ DN2 B cell subset has been previously studied in some autoimmune diseases. A distinct IgD-CD27-CXCR5-CD11c- DN3 B cell subset accumulates in the blood both in IgG4-related disease, an autoimmune disease in which inflammation and fibrosis can be reversed by B cell depletion, and in severe COVID-19. These DN3 B cells prominently accumulate in the end organs of IgG4-related disease and in lung lesions in COVID-19, and double-negative B cells prominently cluster with CD4+ T cells in these lesions. Extrafollicular DN3 B cells may participate in tissue inflammation and fibrosis in autoimmune fibrotic dis-eases, as well as in COVID-19.

引用

页数：16

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