Extrafollicular IgD-CD27-CXCR5-CD11c-DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19

被引：25

作者：

Allard-Chamard, Hugues ^{[1
,2
]}

Kaneko, Naoki ^{[1
,3
]}

Bertocchi, Alice ^{[1
]}

Sun, Na ^{[1
]}

Boucau, Julie ^{[1
]}

Kuo, Hsiao-Hsuan ^{[1
]}

Farmer, Jocelyn R. ^{[1
]}

Perugino, Cory ^{[1
,4
]}

Mahajan, Vinay S. ^{[1
]}

Murphy, Samuel J. H. ^{[1
]}

Premo, Katherine ^{[1
]}

Diefenbach, Thomas ^{[1
]}

Ghebremichael, Musie ^{[1
]}

Yuen, Grace ^{[1
]}

Kotta, Alekhya ^{[1
]}

Akman, Zafer ^{[1
]}

Lichterfeld, Mathias ^{[1
,6
]}

Walker, Bruce D. ^{[1
,7
,8
]}

Yu, Xu G. ^{[3
]}

Moriyama, Masafumi ^{[3
]}

Maehara, Takashi ^{[1
,3
]}

Nakamura, Seiji ^{[3
]}

Stone, John H. ^{[4
]}

Padera, Robert F. ^{[5
]}

Pillai, Shiv ^{[1
]}

机构：

[1] MIT & Harvard, Ragon Inst MGH, Cambridge, MA 02139 USA

[2] Univ Sherbrooke, Fac med & Sci Sante, Ctr Rech Clin Etienne Le Bel, Div Rheumatol, Sherbrooke, PQ J1K 2R1, Canada

[3] Kyushu Univ, Fac Dent Sci, Div Maxillofacial Diagnost & Surg Sci, Sect Oral & Maxillofacial Oncol, Fukuoka, Japan

[4] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02114 USA

[5] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[6] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[7] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[8] MIT, Inst Med Engn & Sci, Dept Biol, Cambridge, MA 02139 USA

来源：

CELL REPORTS | 2023年 / 42卷 / 06期

关键词：

B cell depletion in disease; COVID-19; pathogenesis; CP: Immunology; DN3 B cells; double-negative B cells; extrafollicular B cells; IgG4-related disease; inflammatory fibrosis; T-B collaboration in disease;

D O I：

10.1016/j.celrep.2023.112630

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although therapeutic B cell depletion dramatically resolves inflammation in many diseases in which anti-bodies appear not to play a central role, distinct extrafollicular pathogenic B cell subsets that accumulate in disease lesions have hitherto not been identified. The circulating immunoglobulin D (IgD)-CD27- CXCR5-CD11c+ DN2 B cell subset has been previously studied in some autoimmune diseases. A distinct IgD-CD27-CXCR5-CD11c- DN3 B cell subset accumulates in the blood both in IgG4-related disease, an autoimmune disease in which inflammation and fibrosis can be reversed by B cell depletion, and in severe COVID-19. These DN3 B cells prominently accumulate in the end organs of IgG4-related disease and in lung lesions in COVID-19, and double-negative B cells prominently cluster with CD4+ T cells in these lesions. Extrafollicular DN3 B cells may participate in tissue inflammation and fibrosis in autoimmune fibrotic dis-eases, as well as in COVID-19.

引用

页数：16

共 32 条

[1] Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems [J].

Barisione, Emanuela ;

Grillo, Federica ;

Ball, Lorenzo ;

Bianchi, Rita ;

Grosso, Marco ;

Morbini, Patrizia ;

Pelosi, Paolo ;

Patroniti, Nicolo Antonino ;

De Lucia, Arduino ;

Orengo, Giovanni ;

Gratarola, Angelo ;

Verda, Marta ;

Cittadini, Giuseppe ;

Mastracci, Luca ;

Fiocca, Roberto .

VIRCHOWS ARCHIV, 2021, 478 (03) :471-485

[2] Lung transplantation for patients with severe COVID-19 [J].

Bharat, Ankit ;

Querrey, Melissa ;

Markov, Nikolay S. ;

Kim, Samuel ;

Kurihara, Chitaru ;

Garza-Castillon, Rafael ;

Manerikar, Adwaiy ;

Shilatifard, Ali ;

Tomic, Rade ;

Politanska, Yuliya ;

Abdala-Valencia, Hiam ;

Yeldandi, Anjana, V ;

Lomasney, Jon W. ;

Misharin, Alexander, V ;

Budinger, G. R. Scott .

SCIENCE TRANSLATIONAL MEDICINE, 2020, 12 (574)

[3] Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells [J].

Castleman, Moriah J. ;

Stumpf, Megan M. ;

Therrien, Nicholas R. ;

Smith, Mia J. ;

Lesteberg, Kelsey E. ;

Palmer, Brent E. ;

Maloney, James P. ;

Janssen, William J. ;

Mould, Kara J. ;

Beckham, J. David ;

Pelanda, Roberta ;

Torres, Raul M. .

FRONTIERS IN IMMUNOLOGY, 2022, 13

[4]

Das Karuna M, 2017, Indian J Radiol Imaging, V27, P342, DOI 10.4103/ijri.IJRI_469_16

[5] B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease [J].

Della-Torre, Emanuel ;

Rigamonti, Elena ;

Perugino, Cory ;

Baghai-Sain, Simona ;

Sun, Na ;

Kaneko, Naoki ;

Maehara, Takashi ;

Rovati, Lucrezia ;

Ponzoni, Maurilio ;

Milani, Raffaella ;

Lanzillotta, Marco ;

Mahajan, Vinay ;

Mattoo, Hamid ;

Molineris, Ivan ;

Deshpande, Vikram ;

Stone, John H. ;

Falconi, Massimo ;

Manfredi, Angelo A. ;

Pillai, Shiv .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 145 (03) :968-+

[6] B-cell depletion attenuates serological biomarkers of fibrosis and myofibroblast activation in IgG4-related disease [J].

Della-Torre, Emanuel ;

Feeney, Eoin ;

Deshpande, Vikram ;

Mattoo, Hamid ;

Mahajan, Vinay ;

Kulikova, Maria ;

Wallace, Zachary S. ;

Carruthers, Mollie ;

Chung, Raymond T. ;

Pillai, Shiv ;

Stone, John H. .

ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 (12) :2236-2243

[7] Microscopy-Based multicolor tissue Cytometry at the single-cell level [J].

Eckert, RC ;

Steiner, GE .

CYTOMETRY PART A, 2004, 59A (02) :182-190

[8] Induction of metabolic quiescence defines the transitional to follicular B cell switch [J].

Farmer, Jocelyn R. ;

Allard-Chamard, Hugues ;

Sun, Na ;

Ahmad, Maimuna ;

Bertocchi, Alice ;

Mahajan, Vinay S. ;

Aicher, Toby ;

Arnold, Johan ;

Benson, Mark D. ;

Morningstar, Jordan ;

Barmettler, Sara ;

Yuen, Grace ;

Murphy, Samuel J. H. ;

Walter, Jolan E. ;

Ghebremichael, Musie ;

Shalek, Alex K. ;

Batista, Facundo ;

Gerszten, Robert ;

Pillai, Shiv .

SCIENCE SIGNALING, 2019, 12 (604)

[9] Profound Treg perturbations correlate with COVID-19 severity [J].

Galvan-Pena, Silvia ;

Leon, Juliette ;

Chowdhary, Kaitavjeet ;

Michelson, Daniel A. ;

Vijaykumar, Brinda ;

Yang, Liang ;

Magnuson, Angela ;

Manickas-Hill, Zachary ;

Piechocka-Trocha, Alicja ;

Worrall, Daniel P. ;

Hall, Kathryn E. ;

Ghebremichael, Musie ;

Walker, Bruce D. ;

Li, Jonathan Z. ;

Yu, Xu G. ;

Mathis, Diane ;

Benoist, Christophe .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (37)

[10] Lung fibrosis: an undervalued finding in COVID-19 pathological series [J].

Grillo, Federica ;

Barisione, Emanuela ;

Ball, Lorenzo ;

Mastracci, Luca ;

Fiocca, Roberto .

LANCET INFECTIOUS DISEASES, 2020, 21 (04) :E72-E72

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