A three-dimensional double-helical structure microfluidic chip with efficient mixing

被引:1
|
作者
Yang, Hanbo
Li, Gang
Liu, Huan
Pan, Hongxu
Quan, Jingran
Chen, Yansong
Xu, Jianxin
Liu, Yahao
Li, Lixiang
Wang, Junyao
机构
[1] Jilin, China
基金
中国国家自然科学基金;
关键词
Microfluidic; Three-dimensional; Mixing; MICROMIXER;
D O I
10.1007/s10404-023-02658-z
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
In recent years, the mechanism based on changing the cross-sectional shape of long and straight channels for increasing mixing efficiency has reached a bottleneck, while the vortex effect brought by curved channels has become a hot topic in current mixer research. The vortex effect should be fully utilized in the mixing process. Inspired by the spiral structure as well as splitting and reorganization, a passive three-dimensional double-helical structure micro-mixer was proposed. It is printed by FDM (fused deposition) technology. First, a model of the double-helix structure was printed with HIPS (high impact polystyrene) material, which was supported by PVA (polyvinyl alcohol) material. The mixing experiments showed that the three-dimensional (3D) double-helix structure could increase the mixing efficiency to 90.6%, while the mixing efficiency of the conventional two-dimensional (2D) T-shaped structure was only 78.5%. In this paper, the effects of the number of turns, pitch, diameter, staggering angle, and flow rate on the mixing effect are compared separately. The results show that the change of staggering angle has a better effect on the improvement of mixing efficiency.
引用
收藏
页数:16
相关论文
共 50 条
  • [21] Confocal microscopic evaluation of mixing performance for three-dimensional microfluidic mixer
    Yasui, Takao
    Omoto, Yusuke
    Osato, Keiko
    Kaji, Noritada
    Suzuki, Norikazu
    Naito, Toyohiro
    Okamoto, Yukihiro
    Tokeshi, Manabu
    Shamoto, Eiji
    Baba, Yoshinobu
    Analytical Sciences, 2012, 28 (01): : 57 - 60
  • [22] Confocal Microscopic Evaluation of Mixing Performance for Three-Dimensional Microfluidic Mixer
    Yasui, Takao
    Omoto, Yusuke
    Osato, Keiko
    Kaji, Noritada
    Suzuki, Norikazu
    Naito, Toyohiro
    Okamoto, Yukihiro
    Tokeshi, Manabu
    Shamoto, Eiji
    Baba, Yoshinobu
    ANALYTICAL SCIENCES, 2012, 28 (01) : 57 - 59
  • [23] Multiphoton imaging for three-dimensional characterization of mixing dynamics in a microfluidic device
    Schafer, Dawn
    Amir, Wafa
    Gibson, Emily A.
    Marr, David W. M.
    Jimenez, Ralph
    Squier, Jeff
    BIOPHYSICAL JOURNAL, 2007, : 5A - 6A
  • [24] Microfluidic baker's transformation device for three-dimensional rapid mixing
    Yasui, Takao
    Omoto, Yusuke
    Osato, Keiko
    Kaji, Noritada
    Suzuki, Norikazu
    Naito, Toyohiro
    Watanabe, Masaki
    Okamoto, Yukihiro
    Tokeshi, Manabu
    Shamoto, Eiji
    Baba, Yoshinobu
    LAB ON A CHIP, 2011, 11 (19) : 3356 - 3360
  • [25] Confocal Microscopic Evaluation of Mixing Performance for Three-Dimensional Microfluidic Mixer
    Takao Yasui
    Yusuke Omoto
    Keiko Osato
    Noritada Kaji
    Norikazu Suzuki
    Toyohiro Naito
    Yukihiro Okamoto
    Manabu Tokeshi
    Eiji Shamoto
    Yoshinobu Baba
    Analytical Sciences, 2012, 28 : 57 - 59
  • [26] Three-dimensional microfluidic structure embedded in photostructurable glass by femtosecond laser for lab-on-chip applications
    Sugioka, K
    Masuda, M
    Hongo, T
    Cheng, Y
    Shihoyama, K
    Midorikawa, K
    APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 2004, 79 (4-6): : 815 - 817
  • [27] Three-dimensional microfluidic structure embedded in photostructurable glass by femtosecond laser for lab-on-chip applications
    K. Sugioka
    M. Masuda
    T. Hongo
    Y. Cheng
    K. Shihoyama
    K. Midorikawa
    Applied Physics A, 2004, 79 : 815 - 817
  • [28] Design and Validation of a Microfluidic Chip with Micropillar Arrays for Three-dimensional Cell Culture
    Liu Jun-Shan
    Zhang Yang-Yang
    Wang Zhong
    Deng Jia-Yi
    Ye Xuan
    Xue Ri-Ye
    Ge Dan
    Xu Zheng
    CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2017, 45 (08) : 1109 - 1114
  • [29] Dielectrophoretic Separation of Particles Using Microfluidic Chip with Composite Three-Dimensional Electrode
    Chen, Li
    Liu, Xing
    Zheng, Xiaolin
    Zhang, Xiaoling
    Yang, Jun
    Tian, Tian
    Liao, Yanjian
    MICROMACHINES, 2020, 11 (07)
  • [30] Three-Dimensional Structure of TspO by Electron Cryomicroscopy of Helical Crystals
    Korkhov, Vladimir M.
    Sachse, Carsten
    Short, Judith M.
    Tate, Christopher G.
    STRUCTURE, 2010, 18 (06) : 677 - 687