First-phase insulin secretion: can its evaluation direct therapeutic approaches?

被引：14

作者：

Di Giuseppe, Gianfranco ^{[1
,2
]}

Ciccarelli, Gea ^{[1
,2
]}

Soldovieri, Laura ^{[1
,2
]}

Capece, Umberto ^{[1
,2
]}

Cefalo, Chiara M. A. ^{[1
,2
,4
]}

Moffa, Simona ^{[1
,2
]}

Nista, Enrico C. ^{[2
,3
]}

Brunetti, Michela ^{[1
,2
]}

Cinti, Francesca ^{[1
,2
]}

Gasbarrini, Antonio ^{[2
,3
]}

Pontecorvi, Alfredo ^{[1
,2
]}

Giaccari, Andrea ^{[1
,2
]}

Mezza, Teresa ^{[2
,3
]}

机构：

[1] Fdn Policlin Univ Agostino Gemelli, Endocrinol & Diabetol, Ist Ricovero & Cura Carattere Sci IRCCS, Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslazionale, Rome, Italy

[3] Fdn Policlin Univ Agostino Gemelli, Digest Dis Ctr, IRCCS, Rome, Italy

[4] Univ Rome Sapienza, Dept Clin & Mol Med, Rome, Italy

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2023年 / 34卷 / 04期

关键词：

BETA-CELL FUNCTION; IMPAIRED GLUCOSE-TOLERANCE; GLUCAGON-LIKE PEPTIDE-1; RECEPTOR AGONIST TIRZEPATIDE; POSTPRANDIAL PLASMA-GLUCOSE; GLYCEMIC CONTROL; DOUBLE-BLIND; DIABETES-MELLITUS; INCRETIN HORMONES; POSTMEAL GLUCOSE;

D O I：

10.1016/j.tem.2023.02.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our work is aimed at unraveling the role of the first-phase insulin secretion in the natural history of type 2 diabetes mellitus (T2DM) and its interrelationship with insulin resistance and with beta cell function and mass. Starting from pathophysiology, we investigate the impact of impaired secretion on glucose homeostasis and explore postmeal hyperglycemia as the main clinical feature, underlining its rele-vance in the management of the disease. We also review dietary and pharmaco-logical approaches aimed at improving early secretory defects and restoring residual beta cell function. Furthermore, we discuss possible approaches to detect early secretory defects in clinical practice. By providing a journey through human and animal data, we attempt a unification of the recent evidence in an effort to offer a new outlook on beta cell secretion.

引用

页码：216 / 230

页数：15

共 150 条

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