Plasma-Enabled Graphene Quantum Dot Hydrogels as Smart Anticancer Drug Nanocarriers

被引：37

作者：

Kurniawan, Darwin ^{[1
]}

Mathew, Jacob ^{[1
]}

Rahardja, Michael Ryan ^{[1
]}

Pham, Hoang-Phuc ^{[1
]}

Wong, Pei-Chun ^{[2
]}

Rao, Neralla Vijayakameswara ^{[1
]}

Ostrikov, Kostya ^{[3
,4
]}

Chiang, Wei-Hung ^{[1
]}

机构：

[1] Natl Taiwan Univ Sci & Technol, Dept Chem Engn, Taipei 10607, Taiwan

[2] Taipei Med Univ, Grad Inst Biomed Optomechatron, Coll Biomed Engn, Taipei 110, Taiwan

[3] Queensland Univ Technol QUT, Sch Chem & Phys, Brisbane, Qld 4000, Australia

[4] Queensland Univ Technol QUT, Ctr Mat Sci, Brisbane, Qld 4000, Australia

来源：

SMALL | 2023年 / 19卷 / 20期

基金：

澳大利亚研究理事会;

关键词：

anti-cancer; graphene quantum dots; hydrogels; nanotechnology; plasmas; CARBON DOTS; PH; DELIVERY; NANOPARTICLES; CELLS;

D O I：

10.1002/smll.202206813

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One of the major challenges on the way to low-cost, simple, and effective cancer treatments is the lack of smart anticancer drug delivery materials with the requisite of site-specific and microenvironment-responsive properties. This work reports the development of plasma-engineered smart drug nanocarriers (SDNCs) containing chitosan and nitrogen-doped graphene quantum dots (NGQDs) for drug delivery in a pH-responsive manner. Through a customized microplasma processing, a highly cross-linked SDNC with only 4.5% of NGQD ratio can exhibit enhanced toughness up to threefold higher than the control chitosan group, avoiding the commonly used high temperatures and toxic chemical cross-linking agents. The SDNCs demonstrate improved loading capability for doxorubicin (DOX) via pi-pi interactions and stable solid-state photoluminescence to monitor the DOX loading and release through the Forster resonance energy transfer (FRET) mechanism. Moreover, the DOX loaded SDNC exhibits anticancer effects against cancer cells during cytotoxicity tests at minimum concentration. Cellular uptake studies confirm that the DOX loaded SDNC can be successfully internalized into the nucleus after 12 h incubation period. This work provides new insights into the development of smart, environmental-friendly, and biocompatible nanographene hydrogels for the next-generation biomedical applications.

引用

页数：13

共 62 条

[1] Nitrogen-doped graphene quantum dots for 80% photoluminescence quantum yield for inorganic -CsPbI3 perovskite solar cells with efficiency beyond 16% [J].