A review on organophosphate esters: Physiochemical properties, applications, and toxicities as well as occurrence and human exposure in dust environment

Organophosphate esters (OPEs) are widely used as flame retardants and plasticizers in the world. The use of OPEs has increased rapidly due to the prohibition of polybrominated diphenyl ethers. However, OPEs are mainly added to various materials by physical mixing, they are therefore easy to be released into the environment through volatilization, leaching, and abrasion during their production, use, transportation, and after disposal. Dust, as an important medium for human exposure to OPEs, has attracted extensive attention. Here, this article reviewed the current knowledge on the physiochemical properties, consumptions and applications, and ecotoxicities of OPEs, also synthesized the available data on the occurrence of 13 OPEs in outdoor and indoor dust environments around the world over the past decade. The results showed that the sum of OPEs (sigma OPEs) was the highest in outdoor dust from an e-waste disposal area in Tianjin of China (range: 1390-42700 ng/g dw; mean: 11500 ng/g dw). The highest sigma OPEs was found in Japan for home dust (range: 9300-11000000 ng/g dw; mean: 266543 ng/g dw), Sweden for office dust (range: 14000-1600000 ng/g dw; mean: 360100 ng/g dw) and daycare center dust (range: 40000-4600000 ng/g dw; mean: 1990800 ng/g dw), and Brazil for car dust (range: 108000-2050000 ng/g dw; mean: 541000 ng/g dw). The use pattern of OPEs differed in different regions and countries. The exposure and risk assessment based on the data of OPEs in home dust indicated that the average daily intakes of OPEs via dust ingestion for children and adults were lower than the corresponding reference doses; and that the current human exposure to OPEs through indoor dust ingestion were not likely to pose risks to human health. Finally, the review pointed out the gaps of current research and provided the directions for further study on OPEs in dust environment.