Tuning macrophages for atherosclerosis treatment

被引:39
作者
Fang, Fei [1 ,2 ,3 ]
Xiao, Crystal [2 ,3 ]
Li, Chunli [1 ]
Liu, Xiaoheng [1 ]
Li, Song [2 ,3 ]
机构
[1] Sichuan Univ, Inst Biomed Engn, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China
[2] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA
基金
中国国家自然科学基金;
关键词
macrophages; atherosclerosis; drug delivery system; immune engineering; SMOOTH-MUSCLE-CELLS; TARGETED DELIVERY; NANOPARTICLES; AUTOPHAGY; CHOLESTEROL; INFLAMMATION; MONOCYTOSIS; INHIBITION; PHENOTYPE; HYPERCHOLESTEROLEMIA;
D O I
10.1093/rb/rbac103
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Atherosclerosis is a chronic inflammatory vascular disease and a leading cause of death worldwide. Macrophages play an important role in inflammatory responses, cell-cell communications, plaque growth and plaque rupture in atherosclerotic lesions. Here, we review the sources, functions and complex phenotypes of macrophages in the progression of atherosclerosis, and discuss the recent approaches in modulating macrophage phenotype and autophagy for atherosclerosis treatment. We then focus on the drug delivery strategies that target macrophages or use macrophage membrane-coated particles to deliver therapeutics to the lesion sites. These biomaterial-based approaches that target, modulate or engineer macrophages have broad applications for disease therapies and tissue regeneration.
引用
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页数:14
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