Ion Mobility Mass Spectrometry for Large Synthetic Molecules: Expanding the Analytical Toolbox

被引:12
|
作者
Geue, Niklas [1 ]
Winpenny, Richard E. P. [2 ]
Barran, Perdita E. [1 ]
机构
[1] Univ Manchester, Manchester Inst Biotechnol, Michael Barber Ctr Collaborat Mass Spectrometry, Dept Chem, Manchester M1 7DN, England
[2] Univ Manchester, Dept Chem, Manchester M13 9PL, England
基金
英国工程与自然科学研究理事会; 欧洲研究理事会; 欧盟地平线“2020”;
关键词
GAS-PHASE SYNTHESIS; COLLISION CROSS-SECTIONS; COORDINATION-COMPLEXES; STRUCTURAL-ANALYSIS; CLUSTER; REACTIVITY; CATIONS; FULLERENES; POLYMERS; INSIGHTS;
D O I
10.1021/jacs.4c00354
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Understanding the composition, structure and stability of larger synthetic molecules is crucial for their design, yet currently the analytical tools commonly used do not always provide this information. In this perspective, we show how ion mobility mass spectrometry (IM-MS), in combination with tandem mass spectrometry, complementary techniques and computational methods, can be used to structurally characterize synthetic molecules, make and predict new complexes, monitor disassembly processes and determine stability. Using IM-MS, we present an experimental and computational framework for the analysis and design of complex molecular architectures such as (metallo)supramolecular cages, nanoclusters, interlocked molecules, rotaxanes, dendrimers, polymers and host-guest complexes.
引用
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页码:8800 / 8819
页数:20
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