In vitro activity of tubercidin against Mycobacterium tuberculosis and nontuberculosis Mycobacteria

被引：2
作者：
Sun, Qing [1 ]
Liao, Xinlei [2 ]
Yan, Jun [2 ]
Jiang, Guanglu [1 ]
Huo, Fengmin [1 ]
Wang, Guirong [2 ]
Li, Hao [3 ,4 ]
机构：
[1] Capital Med Univ, Beijing TB & Thorac Tumor Inst, Beijing Chest Hosp, Natl Clin Lab TB, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Inst, Dept Clin Lab, Beijing, Peoples R China
[3] China Agr Univ, Coll Vet Med, Beijing, Peoples R China
[4] Tsinghua Univ, Ctr Infect Dis Res, Sch Med, Beijing, Peoples R China
来源：
JOURNAL OF MEDICAL MICROBIOLOGY | 2023年 / 72卷 / 11期
基金：
中国国家自然科学基金;
关键词：
tubercidin; Mycobacterium tuberculosis; nontuberculosis mycobacteria; tuberculosis; COMBINATION THERAPY; ABSORPTION; TOXICITY;
D O I：
10.1099/jmm.0.001763
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tubercidin is an adenosine analogue that has been shown to exhibit good activity against some tumours and parasites. In this study, the in vitro activity of tubercidin was evaluated against Mycobacterium tuberculosis (Mtb) and nontuberculosis Mycobacteria (NTM). For determining the MICs of tubercidin, 23 fully drug- sensitive (DS) Mtb strains, 33 multi- drug resistance tubertuberculosis (XDR- TB) strains, 17 rapidly growing mycobacteria (RGM) and nine slowly growing mycobacteria (SGM) references strains were tested by microplate- based Alamar Blue assay (MABA) method. The results indicate that tubercidin has high in vitro activity against some drug- resistance Mtb strains and NTM reference strains, which warrants further investigation on the actions of tubercidin and its derivatives as potential drugs for mycobacterial infections.
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页数：4
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