In vitro activity of tubercidin against Mycobacterium tuberculosis and nontuberculosis Mycobacteria

被引：2

作者：

Sun, Qing ^{[1
]}

Liao, Xinlei ^{[2
]}

Yan, Jun ^{[2
]}

Jiang, Guanglu ^{[1
]}

Huo, Fengmin ^{[1
]}

Wang, Guirong ^{[2
]}

Li, Hao ^{[3
,4
]}

机构：

[1] Capital Med Univ, Beijing TB & Thorac Tumor Inst, Beijing Chest Hosp, Natl Clin Lab TB, Beijing, Peoples R China

[2] Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Inst, Dept Clin Lab, Beijing, Peoples R China

[3] China Agr Univ, Coll Vet Med, Beijing, Peoples R China

[4] Tsinghua Univ, Ctr Infect Dis Res, Sch Med, Beijing, Peoples R China

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2023年 / 72卷 / 11期

基金：

中国国家自然科学基金;

关键词：

tubercidin; Mycobacterium tuberculosis; nontuberculosis mycobacteria; tuberculosis; COMBINATION THERAPY; ABSORPTION; TOXICITY;

D O I：

10.1099/jmm.0.001763

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Tubercidin is an adenosine analogue that has been shown to exhibit good activity against some tumours and parasites. In this study, the in vitro activity of tubercidin was evaluated against Mycobacterium tuberculosis (Mtb) and nontuberculosis Mycobacteria (NTM). For determining the MICs of tubercidin, 23 fully drug- sensitive (DS) Mtb strains, 33 multi- drug resistance tubertuberculosis (XDR- TB) strains, 17 rapidly growing mycobacteria (RGM) and nine slowly growing mycobacteria (SGM) references strains were tested by microplate- based Alamar Blue assay (MABA) method. The results indicate that tubercidin has high in vitro activity against some drug- resistance Mtb strains and NTM reference strains, which warrants further investigation on the actions of tubercidin and its derivatives as potential drugs for mycobacterial infections.

引用

页数：4

共 50 条

[1] In vitro activity of fidaxomicin against nontuberculosis mycobacteria
Sun, Qing
Liao, Xinlei
Wang, Chenqian
Jiang, Guanglu
Yang, Jing
Zhao, Jianhong
Huang, Hairong
Wang, Guirong
Li, Hao
JOURNAL OF MEDICAL MICROBIOLOGY, 2022, 71 (06)
[2] ACTIVITY OF GENTAMICIN AGAINST MYCOBACTERIA IN-VITRO AND AGAINST MYCOBACTERIUM-TUBERCULOSIS IN MICE
SANDERS, WE
PEJOVIC, I
CACCIATORE, R
VALDEZ, H
DUNBAR, FP
JOURNAL OF INFECTIOUS DISEASES, 1971, 124 (DEC): : S33 - +
[3] COMPARATIVE ACTIVITY OF SISOMICIN AGAINST MYCOBACTERIA IN-VITRO ND AGAINST MYCOBACTERIUM-TUBERCULOSIS IN MICE
PEJOVIC, I
CACCIATORE, R
VALDEZ, H
DUNBAR, FP
SANDERS, WE
JOURNAL OF INFECTIOUS DISEASES, 1973, 127 (06): : 720 - 722
[4] In Vitro Activity of a New Isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and Other Mycobacteria
Molina-Torres, Carmen A.
Ocampo-Candiani, Jorge
Rendon, Adrian
Pucci, Michael J.
Vera-Cabrera, Lucio
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (05) : 2188 - 2190
[5] Exosomal MicroRNAs as a Novel Diagnostic Biomarker for Rapid Detection of Mycobacterium tuberculosis and Nontuberculosis Mycobacteria
Javadi, Alireza
BIOMEDICAL AND BIOTECHNOLOGY RESEARCH JOURNAL, 2024, 8 : S1 - S1
[6] In Vitro Activity of Tedizolid against Mycobacterium tuberculosis
Ruiz, Pilar
Causse, Manuel
Vaquero, Manuel
Casal, Manuel
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 63 (04)
[7] In vitro activity of ofloxacin against Mycobacterium tuberculosis
Yu, MC
Suo, J
Lin, TP
Luh, KT
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 1997, 96 (01) : 13 - 16
[8] In vitro activity of Fluoroquinolones against Mycobacterium tuberculosis
Sulochana, S
Rahman, F
Paramasivan, CN
JOURNAL OF CHEMOTHERAPY, 2005, 17 (02) : 169 - 173
[9] In vitro Activity of Repurposed Nitroxoline Against Clinically Isolated Mycobacteria Including Multidrug-Resistant Mycobacterium tuberculosis
Hoffmann, Ada Marie
Wolke, Martina
Rybniker, Jan
Plum, Georg
Fuchs, Frieder
FRONTIERS IN PHARMACOLOGY, 2022, 13
[10] Investigation of the in vitro activity of streptomycin against Mycobacterium tuberculosis
Ruiz, P
Rodríguez-Cano, F
Zerolo, FJ
Casal, M
MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 2002, 8 (02): : 147 - 149

← 1 2 3 4 5 →