With the rapid growth of area industrial load and the lagging construction of main area power plants, a large amount of power has to be transmitted from the outside. After the fault trip of the double-line in the same corridor, security and stability control (SSC) measures have to be taken for stability of the load intensive area. In order to verify the correctness and reliability of the control strategy, this paper carried out the hardware-in-the-loop test of the SSC system based on the large power grid real-time simulation technology, and found that there was a serious voltage instability risk and the SSC system refusing to act in the area. Based on the mechanism analysis of voltage instability of induction motor, the voltage instability process of the load intensive area has been studied. Then, the SSC strategy has been optimized to eliminate the risk of the SSC system refusing to act. This case study shows that the real-time simulation technology based on large power grid has obvious advantages in the research of SSC strategy, especially in the research of power grid electromagnetic transient closed-loop response with the participation of SSC system.