Factors associated with survival in paediatric and adolescent renal cell carcinoma: a population-based study

被引:0
作者
Zhao, Lingling [1 ]
Liu, Wenyuan [2 ]
Chu, Likai [3 ]
Luo, Laiyue [4 ]
机构
[1] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Dept Pathol, Hangzhou, Peoples R China
[2] Anhui Med Univ, Hosp 2, Dept Pediat, Hefei, Peoples R China
[3] Soochow Univ, Childrens Hosp, Dept Ultrasound, Suzhou, Peoples R China
[4] Zhejiang Univ, Affiliated Hosp 1, Anji Cty Peoples Hosp, Dept Nephrol,Anji Branch, Huzhou 313300, Peoples R China
关键词
paediatric renal cell carcinoma; surveillance; epidemiology and end results (SEER); survival; translocation renal cell carcinoma (tRCC); RACIAL DISPARITY; CANCER SURVIVAL; CHILDREN; WHITES;
D O I
10.1111/ans.18614
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: The purpose of this study was to conduct a population-based study to determine the prognosis of renal cell carcinoma (RCC) in children and adolescents.Methods: Patients with RCC who were registered in the Surveillance, Epidemiology, and End Results (SEER) program between 2000 and 2018 had their demographic and clinical characteristics evaluated retrospectively. The log-rank test was used to compare survival curves. Kaplan-Meier estimates were used to generate survival curves based on various factors. To identify factors associated with overall survival, Cox proportional-hazards regression was used.Results: A total of 251 patients were enrolled in the study. For all patients, the overall survival (OS) rates at 3- and 5- year were 93.5% and 92.0%, respectively. A multivariable study revealed that the following factors were independently associated with overall survival: sex, race, histologic type, SEER stage, AJCC stage, and type of surgery. Cox analysis showed that white patients had the lowest risk of mortality (hazard ratio (HR) 2.58, 95% confidence interval (CI), 1.33-4.99; P = 0.005), compared with black patients. Patients having metastatic disease had significantly higher mortality risk (HR 43, 95% CI, 14.8-125; P < 0.001) than the patients with localized tumour.Conclusions: Our study emphasizes the importance of race, SEER stage, and surgery in the prognosis of paediatric RCC, providing valuable epidemiological evidence for clinical practice. Economic studies assessing a race/ethnic group specific strategy are also required.
引用
收藏
页码:2710 / 2715
页数:6
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