Phaeohyphomycosis in Solid Organ Transplant Recipients: A Case Series and Narrative Review of the Literature

被引:3
作者
Lo Porto, Davide [1 ]
Cona, Andrea [1 ]
Todaro, Francesca [1 ]
De Carolis, Elena [2 ]
Cardinale, Francesca [1 ]
Hafeez, Neha [3 ]
Di Martino, Giuseppina [1 ]
Conaldi, Pier Giulio [1 ]
Sanguinetti, Maurizio [2 ]
Grossi, Paolo Antonio [4 ]
Mularoni, Alessandra [1 ]
机构
[1] ISMETT IRCCS Ist Mediterraneo Trapianti & Terapie, Unit Infect Dis, Via E Tricomi 5, I-90127 Palermo, Italy
[2] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Lab & Infettivol, I-00168 Rome, Italy
[3] Univ Pittsburgh, Dept Med, Sch Med, Pittsburgh, PA 15261 USA
[4] Univ Insubria ASST Sette Laghi, Dept Med & Surg, Infect & Trop Dis Unit, I-21100 Varese, Italy
关键词
Alternaria alternata; Alternaria infectoria; Curvularia hawaiiensis; phaeohyphomycosis; SOT; voriconazole; itraconazole; posaconazole; transplantation; CUTANEOUS PHEOHYPHOMYCOSIS; ALTERNARIA-INFECTORIA; BRAIN-ABSCESS; SUBCUTANEOUS PHEOHYPHOMYCOSIS; PHAEOACREMONIUM PARASITICUM; CLADOPHIALOPHORA-BANTIANA; PYRENOCHAETA-ROMEROI; INFECTION; PATIENT; DIAGNOSIS;
D O I
10.3390/jof9030283
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Phaeohyphomycosis comprises a variety of infections caused by pigmented fungi. Solid organ transplant (SOT) recipients are particularly at risk of invasive infections due to their prolonged immunosuppression. Here, we describe three cases of phaeohyphomycosis in SOT recipients who were successfully treated with surgical excision and/or antifungal therapy. We additionally carried out a narrative review of the literature on phaeohyphomycosis in 94 SOT recipients from 66 published studies describing 40 different species of fungi. The most reported fungus was Alternaria (21%). The median time from transplant to diagnosis was 18 months (IQR 8.25-48), and kidney transplants were the most reported. Antifungal regimens were not homogeneous, though there was a prevalence of itraconazole- and voriconazole-based treatments. Clinical outcomes included recovery in 81% and death in 5% of infected SOT recipients. Susceptibility testing was done in 26.6% of the cases, with heterogeneous results due to the variety of species isolated. While the wide diversity of dematiaceous fungi and their host range make it difficult to offer a uniform approach for phaeohyphomycosis, an early diagnosis and therapy are critical in preventing the dissemination of disease in the immunocompromised host.
引用
收藏
页数:18
相关论文
共 72 条
  • [1] Disseminated Rhinocladiella mackenziei infection in a kidney transplant recipient: A case report and literature review
    Al Otaibi, Torki M.
    Gheith, Osama A.
    Alobaid, Khaled
    Nair, Prasad
    Eldein, Sohair M. Zein
    Mahmoud, Tarek S.
    Halim, Medhat A.
    Aboatya, Hasaneen H.
    Balaha, Mohamed A.
    Atea, Khalid A.
    Nagib, Ayman Maher
    Al-Hatmi, Abdullah M. S.
    Sadon, Amal
    Meis, Jacques F.
    Zahab, Mohamed
    [J]. JOURNAL DE MYCOLOGIE MEDICALE, 2021, 31 (04):
  • [2] First case of phaeohyphomycosis due to Pleurostoma ootheca in a kidney transplant recipient in Martinique (French West Indies)
    Amazan, E.
    Desbois, N.
    Fidelin, G.
    Baubion, E.
    Derancourt, C.
    Thimon, S.
    Ekindi, N.
    Quist, D.
    [J]. MEDECINE ET SANTE TROPICALES, 2014, 24 (03): : 323 - 325
  • [3] Alternaria infectoria skin infection in a renal transplant recipient: an emerging phaeohyphomycosis of occidental countries?
    Aragon-Miguel, Raquel
    Calleja-Algarra, Alba
    Morales-Raya, Carlos
    Ortiz-Romero, Pablo L.
    Maronas-Jimenez, Lidia
    Lopez-Medrano, Francisco
    Perez-Ayala, Ana
    Rodriguez-Peralto, Jose L.
    [J]. INTERNATIONAL JOURNAL OF DERMATOLOGY, 2017, 56 (07) : E153 - E155
  • [4] Antifungal Susceptibility Testing: Current Approaches
    Berkow, Elizabeth L.
    Lockhart, Shawn R.
    Ostrosky-Zeichner, Luis
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 2020, 33 (03)
  • [5] Cutaneous infection by different Alternaria species in liver trasplant recipient
    Bras, Susana
    Sabino, Raquel
    Laurean, Andre
    Simores, Helena
    Fernandes, Candida
    Marques-Pinto, Gabriela
    Cardoso, Jorge
    Verissimo, Cristina
    [J]. MEDICAL MYCOLOGY CASE REPORTS, 2015, 8 : 1 - 4
  • [6] Phaeohyphomycosis caused by Rhytidhysteron rufulum
    Braue, J. A.
    Larue, R. W., Jr.
    Boyd, A. S.
    Fine, J. -D.
    [J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2020, 45 (04) : 524 - 526
  • [7] Ochroconis Gallopavum Infection in a Lung Transplant Recipient: Report of a Case
    Brokalaki, E. I.
    Sommerwerck, U.
    von Heinegg, E. H.
    Hillen, U.
    [J]. TRANSPLANTATION PROCEEDINGS, 2012, 44 (09) : 2778 - 2780
  • [8] Diffuse primary cutaneous infection by Alternaria alternata in a liver transplant recipient with pulmonary nocardiosis: Importance of prompt identification for clinical resolution
    Campoli, Caterina
    Ferraro, Sara
    Salfi, Nunzio
    Coladonato, Simona
    Morelli, Maria Cristina
    Giannella, Maddalena
    Ambretti, Simone
    Viale, Pier Luigi
    Cricca, Monica
    [J]. MEDICAL MYCOLOGY CASE REPORTS, 2020, 28 : 42 - 45
  • [9] Cerebral phaeohyphomycosis caused by Alternaria spp.: A case report
    Cardona, Santiago
    Yusef, Soad
    Silva, Edwin
    Bustos M, Gisell
    Torres M, Isabel
    Leal A, Rafael
    Ceballos-Garzon, Andres
    Fernando Josa, Diego
    [J]. MEDICAL MYCOLOGY CASE REPORTS, 2020, 27 : 11 - 13
  • [10] ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi
    Chowdhary, A.
    Meis, J. F.
    Guarro, J.
    de Hoog, G. S.
    Kathuria, S.
    Arendrup, M. C.
    Arikan-Akdagli, S.
    Akova, M.
    Boekhout, T.
    Caira, M.
    Guinea, J.
    Chakrabarti, A.
    Dannaoui, E.
    van Diepeningen, A.
    Freiberger, T.
    Groll, A. H.
    Hope, W. W.
    Johnson, E.
    Lackner, M.
    Lagrou, K.
    Lanternier, F.
    Lass-Floerl, C.
    Lortholary, O.
    Meletiadis, J.
    Munoz, P.
    Pagano, L.
    Petrikkos, G.
    Richardson, M. D.
    Roilides, E.
    Skiada, A.
    Tortorano, A. M.
    Ullmann, A. J.
    Verweij, P. E.
    Cornely, O. A.
    Cuenca-Estrella, M.
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 : 47 - 75