Identification of stage I/II melanoma patients at high risk for recurrence using a model combining clinicopathologic factors with gene expression profiling (CP-GEP)

被引:23
作者
Amaral, Teresa [1 ,2 ]
Sinnberg, Tobias [1 ,2 ]
Chatziioannou, Eftychia [1 ]
Niessner, Heike [1 ,2 ]
Leiter, Ulrike [1 ]
Keim, Ulrike [1 ]
Forschner, Andrea [1 ]
Dwarkasing, Jvalini [3 ]
Tjien-Fooh, Felicia [3 ]
Wever, Renske [3 ]
Flatz, Lukas [1 ]
Eggermont, Alexander [3 ,4 ,5 ,6 ]
Forchhammer, Stephan [1 ]
机构
[1] Eberhard Karls Univ Tuebingen, Ctr Dermatooncol, iebermeisterstr 25, Tubingen D-72076, Germany
[2] Cluster Excellence IFIT EXC 2180, Tubingen, Germany
[3] SkylineDx BV, Rotterdam, Netherlands
[4] Tech Univ Munich, Comprehens Canc Ctr Munchen, Munich, Germany
[5] Ludwig Maximiliaan Univ Munich, Munich, Germany
[6] UMC Utrecht, Utrecht, Netherlands
关键词
Stage I; II melanoma; Biomarker; CP-GEP; Risk stratification; Adjuvant therapy; THIN MELANOMAS; IPILIMUMAB;
D O I
10.1016/j.ejca.2022.12.021
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Patients with cutaneous melanoma stage I/IIA disease are currently not eligible for adjuvant therapy, despite their risk for relapses and death. This study validates the ability of a model combining clinicopathologic factors with gene expression profiling (CP-GEP) to identify patients at high risk for disease recurrence in stage I/II and subgroup stage I/IIA.Patients and methods: 543 patients with stage I/II primary cutaneous melanoma from the Uni-versity of Tuebingen diagnosed between 2000 and 2017 were analysed. All patients received sentinel lymph node biopsy (SLNB). Analysis was conducted for a separate group of 80 pa-tients who did not undergo SLNB.Results: CP-GEP stratified 424 stage I/IIA patients (78% of the cohort) according to their risk for recurrence, with five-year relapse-free survival (RFS) rates of 77.8% and 93% for CP-GEP high risk (195 patients) and low risk (229 patients), respectively, and hazard ratio of 3.53 (p- value <0.001). In patients who did not receive SLNB biopsy, CP-GEP captured 6 out of 7 re-lapses.Conclusion: CP-GEP can be used to identify primary cutaneous melanoma patients with a high risk for disease recurrence -especially for stage I/IIA, who are considered low risk by AJCC 8th. These patients may benefit from adjuvant therapy. Also, in the future, when SLNB may become irrelevant, CP-GEP may serve as a risk stratification tool. 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:155 / 162
页数:8
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