Photoinduced [3+2] Cycloaddition of Alkyl-Acceptor Diazoalkanes: Diversity-Oriented Synthesis of Pyrazolines Containing a Quaternary Center

被引：4

作者：

He, Fengya ^{[1
]}

Sun, Ziyi ^{[1
]}

Xu, Yiwei ^{[1
]}

Yu, Jingwen ^{[1
]}

Li, Wenyong ^{[2
]}

Miao, Hui ^{[2
]}

Wu, Chenggui ^{[1
,2
]}

机构：

[1] Anhui Univ Chinese Med, Key Lab Xinan Med, Minist Educ, Hefei 230038, Anhui, Peoples R China

[2] Fuyang Normal Univ, Sch Biol & Food Engn, Anhui Prov Key Lab Environm Hormone & Reprod, Fuyang 236037, Anhui, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 19期

关键词：

FORMAL 4+1 CYCLOADDITION; ENANTIOSELECTIVE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; ASYMMETRIC-SYNTHESIS; CASCADE SYNTHESIS; DIAZO-COMPOUNDS; DIHYDROPYRAZOLES; TRANSFORMATIONS; DERIVATIVES; SELECTIVITY;

D O I：

10.1021/acs.orglett.3c04296

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present a new [3+2] cycloaddition reaction between alkyl-acceptor diazoalkanes under visible light irradiation. By employing easily accessible alkyl-acceptor-type diazoalkanes or their precursor hydrazones as both 1,3-dipoles and dipolarophiles, a diverse range of pyrazoline derivatives featuring a quaternary center have been efficiently synthesized in a predictable manner, with excellent functional group tolerance and good yields. Furthermore, scale-up experiments and downstream transformations of the product were also detailed.

引用

页码：4031 / 4036

页数：6

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