New targets for type 2-low asthma

被引：0

作者：

Quoc, Quang Luu ^{[1
,2
]}

Choi, Youngwoo ^{[3
]}

Hur, Gyu-Young ^{[4
]}

Park, Hae-Sim ^{[1
,2
]}

机构：

[1] Ajou Univ, Sch Med, Dept Allergy & Clin Immunol, 164 Worldcup Ro, Suwon, South Korea

[2] Ajou Univ, Dept Biomed Sci, Grad Sch, Suwon, South Korea

[3] Pusan Natl Univ, Coll Nat Resources & Life Sci, Dept Biomat Sci, BK21 FOUR Program, Miryang, South Korea

[4] Korea Univ, Coll Med, Dept Internal Med, Seoul, South Korea

来源：

KOREAN JOURNAL OF INTERNAL MEDICINE | 2024年 / 39卷 / 02期

关键词：

Asthma; Biomarker; Mechanism; Neutrophil; Therapeutics; NECROSIS-FACTOR-ALPHA; AIRWAY INFLAMMATION; DOUBLE-BLIND; EXTRACELLULAR VESICLES; PERSISTENT ASTHMA; CXCR2; ANTAGONIST; SPUTUM; HETEROGENEITY; MODERATE; BIOMARKERS;

D O I：

10.3904/kjim.2023.299

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Asthma is characterized by airway obstruction and inflammation, and presents significant diagnostic and treatment challenges. The concept of endotypes has improved understanding of the mechanisms of asthma and has stimulated the development of effective treatment strategies. Sputum profiles may be used to classify asthma into two major inflammatory types: type 2-high (T2H) and type 2-low (T2L) asthma. T2H, characterized by elevated type 2 inflammation, has been extensively studied and several effective biologic treatments have been developed. However, managing T2L is more difficult due to the lack of reliable biomarkers for accurate diagnosis and classification. Additionally, conventional anti-inflammatory therapy does not completely control the symptoms of T2L; therefore, further research is needed to identify effective biologic treatments. This review provides new insights into the clinical characteristics and underlying mechanisms of severe T2L and investigates potential therapeutic approaches to control the disease.

引用

页码：215 / 227

页数：13

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