Anaplastic lymphoma kinase-positive histiocytosis with multisystem involvement: A case report

被引：1

作者：

Tu, Yaojun ^{[1
]}

Lu, Yao ^{[1
,2
]}

机构：

[1] Univ Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Dept Dermatol, Chengdu, Peoples R China

[2] Univ Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Dept Dermatol, Chengdu 611731, Peoples R China

来源：

PEDIATRIC DERMATOLOGY | 2024年 / 41卷 / 03期

关键词：

anaplastic lymphoma kinase; histiocytosis; infant;

D O I：

10.1111/pde.15546

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a rare disease that usually occurs in infants and young children and is characterized by ALK-positive histiocytes infiltrating organs. We present a case of multisystem involvement of ALK-positive histiocytosis in a female infant with skin nodules as the initial presentation. Despite multiorgan involvement, most tumors had spontaneously regressed, and all bones were partially healed after 40 months of regular follow-up without treatment. However, gait abnormalities persisted, indicating that early treatment may have greater impact in maintaining a child's quality of life when the disease involves the brain or the critical period of bone development.

引用

页码：551 / 553

页数：3

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