A Promising Optical Bio-Interface: Graded-Index Hydrogel Fiber

被引：4

作者：

Zhuo, Xuan ^{[1
]}

Han, Yaning ^{[1
]}

Bian, Yinxu ^{[1
]}

Xu, Anni ^{[1
]}

Shen, Hua ^{[1
,2
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Elect & Opt Engn, MIIT Key Lab Adv Solid Laser, Nanjing 210094, Peoples R China

[2] Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA

来源：

ADVANCED OPTICAL MATERIALS | 2024年 / 12卷 / 04期

关键词：

3D printing; graded refractive index; optical hydrogel fibers; OPTOGENETICS; POLYMER;

D O I：

10.1002/adom.202301613

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Light in human-machine interactions requires a bio-friendly, efficient, and stable optical bio-interface. Optical hydrogel fibers (HFs) with excellent biocompatibility will advance next-generation implantable optical bio-interfaces. However, the efficiency of HFs is limited by high optical attenuation. Moreover, the stability of implanted HFs is degraded by refraction leakage due to contact with high-refractive-index (RI) tissue and bending losses due to in vivo motion or organ micro-stress. Here, a graded-index hydrogel fiber (GIHF) is created for high-performance, anti-interference optical bio-interface. The gradient RI of GIHF provides a "self-focusing" ability to confine the light field, achieving a high transmittance and resistance to stress bending and interference of high-RI tissue. Additionally, GIHF with optimized RI distribution is fabricated by a projection-suspended photocuring (PSP) 3D printing method. The optical loss (0.25 dB cm-1), tissue-contact transmittance (98%), and bending loss (0.24 dB per 90 degrees) of the developed GIHF indicate that it outperforms other HFs. The GIHF optical bio-interface is used to guide sufficient light to excite fluorescence in phantom brain, and the fluorescence signal is stable under multi-frequency vibration. It paves the way for advances in optogenetics and brain-machine interfaces (BMI).

引用

页数：10