PLA stereocomplex-chitosan nanoparticles loaded with tenofovir alafenamide as a long-acting antiretrovirals

被引：1
|
作者：
Narayanan, Vedha Hari B. [1 ,2 ]
Kost, Bartlomiej [1 ]
Lewandowski, Artur [3 ]
Durai, Ramya Devi [2 ]
Wawrzyniak, Pawel [3 ]
Biela, Tadeusz [1 ]
Wingenfeld, Rieke [4 ]
Sperber, Hannah Sabeth [4 ]
Schwarzer, Roland [4 ]
Brzezinski, Marek [1 ]
机构：
[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Sienkiewicza 112, PL-90363 Lodz, Poland
[2] SASTRA Deemed Univ, Sch Chem & Biotechnol, Pharmaceut Technol Lab, Thanjavur 613401, Tamil Nadu, India
[3] Lodz Univ Technol, Fac Proc & Environm Engn, Dept Environm Engn, Lodz, Poland
[4] Univ Hosp Essen AoR, Inst Translat HIV Res, Virchowstr 171, Essen, Germany
来源：
ADVANCED POWDER TECHNOLOGY | 2023年 / 34卷 / 11期
关键词：
Nanoparticles; Chitosan; Polylactide; Stereocomplex; Long-acting injectable; CONTROLLED-RELEASE; IN-VITRO; DELIVERY; PHARMACOKINETICS; OLEOGELS; FUMARATE; SYSTEM; SPRAY; FOAM;
D O I：
10.1016/j.apt.2023.104205
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Antiretroviral therapy (ART) is a major method of HIV and AIDS treatment; however, it has several limitations, such as poor drug availability, cytotoxicity or renal clearance of the drug molecules. The drugs can be encapsulated in biocompatible polymeric nanocarriers to overcome these limitations. Therefore, the NPs composed of different ratios of poly(L-lactide) PLLA, poly(D-lactide) PDLA, and chitosan (CHI) were prepared by spray-drying technique. Subsequently, the NPs were loaded with the antiretroviral drug - tenofovir alafenamide (TAF). The influence of process variables and nanoparticles (NPs) composition on particle size, drug encapsulation and release was investigated. Finally, it was proved that obtained formulations are non-toxic, and their antiviral efficiency was quantified by JurkatE6 cells infected with HIV. Our findings ascertain that PLLA/PDLA/CHI nanocarriers have great potential for delivering antiHIV therapeutics.(c) 2023 The Society of Powder Technology Japan. Published by Elsevier BV and The Society of Powder Technology Japan. All rights reserved.
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页数：11
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