Aminomethylation of Quercetin by Tetrahydroisoquinoline Derivatives and Their Biological Activity

被引：1

作者：

Zhurakulov, Sh. N. ^{[1
,2
]}

Narbutaeva, D. A. ^{[1
]}

Karakulova, A. M. ^{[1
]}

Tursunkhodzhaeva, F. M. ^{[1
]}

Vinogradova, V. I. ^{[1
]}

机构：

[1] Acad Sci Uzbek, S Yu Yunusov Inst Chem Plant Subst, 77 Mirzo Ulugbek St, Tashkent 100170, Uzbekistan

[2] Mirzo Ulugbek Natl Univ Uzbekistan, 4 Univ Skaya St, Tashkent 100174, Uzbekistan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 04期

关键词：

quercetin; 1-aryltetrahydroisoquinolines; aminomethylation reaction; hypoxia; DIHYDROQUERCETIN; FLAVONOIDS;

D O I：

10.1007/s10600-023-04080-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Monosubstituted quercetin conjugates were synthesized via Mannich reactions from 1-aryl-(or H)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines in 75-96% yields. Compounds with antihypoxic activity more effective than that of quercetin were found among them.

引用

页码：655 / 661

页数：7

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