Aminomethylation of Quercetin by Tetrahydroisoquinoline Derivatives and Their Biological Activity

被引：1
|
作者：
Zhurakulov, Sh. N. [1 ,2 ]
Narbutaeva, D. A. [1 ]
Karakulova, A. M. [1 ]
Tursunkhodzhaeva, F. M. [1 ]
Vinogradova, V. I. [1 ]
机构：
[1] Acad Sci Uzbek, S Yu Yunusov Inst Chem Plant Subst, 77 Mirzo Ulugbek St, Tashkent 100170, Uzbekistan
[2] Mirzo Ulugbek Natl Univ Uzbekistan, 4 Univ Skaya St, Tashkent 100174, Uzbekistan
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 04期
关键词：
quercetin; 1-aryltetrahydroisoquinolines; aminomethylation reaction; hypoxia; DIHYDROQUERCETIN; FLAVONOIDS;
D O I：
10.1007/s10600-023-04080-x
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Monosubstituted quercetin conjugates were synthesized via Mannich reactions from 1-aryl-(or H)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines in 75-96% yields. Compounds with antihypoxic activity more effective than that of quercetin were found among them.
引用
收藏
页码：655 / 661
页数：7
相关论文
共 50 条
  • [1] Aminomethylation of Quercetin by Tetrahydroisoquinoline Derivatives and Their Biological Activity
    Sh. N. Zhurakulov
    D. A. Narbutaeva
    A. M. Karakulova
    F. M. Tursunkhodzhaeva
    V. I. Vinogradova
    Chemistry of Natural Compounds, 2023, 59 : 655 - 661
  • [2] QUERCETIN: DERIVATIVES, BIOSYNTHESIS, BIOLOGICAL ACTIVITY, PHARMACOLOGICAL AND THERAPEUTIC EFFECTS
    Mohammed, Falah Saleh
    Sevindik, Mustafa
    Uysal, Imran
    Sabik, Ali Erdem
    PROSPECTS IN PHARMACEUTICAL SCIENCES, 2023, (03): : 49 - 56
  • [3] Synthesis and Antiviral Activity of Quercetin Brominated Derivatives
    Karimova, Elza
    Baltina, Lidia
    Spirikhin, Leonid
    Gabbasov, Tagir
    Orshanskaya, Yana
    Zarubaev, Vladimir
    NATURAL PRODUCT COMMUNICATIONS, 2015, 10 (09) : 1565 - 1568
  • [4] Facile synthesis of 8-arylated quercetin derivatives and biological activity evaluation
    Shi, Ya-Juan
    Gao, Jian-Wei
    Liu, Chen -Fu
    JOURNAL OF MOLECULAR STRUCTURE, 2022, 1268
  • [5] Investigation of the Antioxidant and Antibacterial Activity of Novel Quercetin Derivatives
    Aljadaan, Shaker A. N.
    Elias, Rita S.
    Al-Anssari, Reham Adnan
    BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2020, 10 (06): : 7329 - 7336
  • [6] O-Glycoside quercetin derivatives: Biological activities, mechanisms of action, and structure-activity relationship for drug design, a review
    Alizadeh, Seyedeh Roya
    Ebrahimzadeh, Mohammad Ali
    PHYTOTHERAPY RESEARCH, 2022, 36 (02) : 778 - 807
  • [7] Enhanced Bioactivity of Quercetin-Tetrahydroisoquinoline Derivatives: Effect on Lipophilicity, Enzymes Inhibition, Antioxidant Potential, and Cytotoxicity
    Vuckovski, Marija
    Filipovic, Ana
    Jadranin, Milka
    Koricanac, Lela
    Zakula, Jelena
    Bondzic, Bojan P.
    Bondzic, Aleksandra M.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (23)
  • [8] Synthesis, characterization and antioxidant activity of quercetin derivatives
    Sun, Lei
    Lu, Bo
    Liu, Yandan
    Wang, Qian
    Li, Gao
    Zhao, Longxuan
    Zhao, Chunhui
    SYNTHETIC COMMUNICATIONS, 2021, 51 (19) : 2944 - 2953
  • [9] Design, Synthesis and Antitumor Activity of Quercetin Derivatives Containing a Quinoline Moiety
    Zhang, Wenting
    Sun, Jian
    Zhang, Peng
    Yue, Ruixue
    Zhang, Yi
    Niu, Fuxiang
    Zhu, Hong
    Ma, Chen
    Deng, Shaoying
    MOLECULES, 2024, 29 (01):
  • [10] Quercetin Suppress Prostatic Cancer Biological Activity In Vitro and Vivo Study
    Su, Zhe
    Liu, Tianjun
    Hong, Ge
    JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2018, 8 (07) : 949 - 961
12345