Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms

被引：9
作者：
Ma, TianRong [1 ]
Xue, XiaoLei [1 ,3 ]
Tian, Hui [4 ]
Zhou, XinXiu [1 ]
Wang, JunKe [1 ]
Zhao, ZhiWen [1 ]
Wang, MingFei [2 ]
Song, JiYuan [2 ]
Feng, RenXiang [2 ]
Li, Leping [1 ,2 ]
Jing, Changqing [1 ,2 ]
Tian, Feng [1 ,2 ]
机构：
[1] Shandong First Med Univ, Dept Gastrointestinal Surg, Shandong Prov Hosp, Jinan 250021, Peoples R China
[2] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Gastrointestinal Surg, Jinan 250021, Peoples R China
[3] Shandong First Med Univ, Dept Pharm, Affiliated Hosp 2, Tai An 271000, Peoples R China
[4] Shandong First Med Univ, Liaocheng Peoples Hosp, Dept Gastroenterol, Liaocheng 252000, Peoples R China
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2023年 / 21卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Gut microbiota; Intestinal motility; Metabolites; Postoperative ileus; Probiotics; Review; IRRITABLE-BOWEL-SYNDROME; ENTERIC NERVOUS-SYSTEM; MAST-CELLS; ABDOMINAL-SURGERY; GASTROINTESTINAL MOTILITY; BACTERIAL TRANSLOCATION; INTERSTITIAL-CELLS; ILEUS; ACTIVATION; SEROTONIN;
D O I：
10.1186/s12967-023-04215-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Gut microbiota is closely related to human health and disease because, together with their metabolites, gut microbiota maintain normal intestinal peristalsis. The use of antibiotics or opioid anesthetics, or both, during surgical procedures can lead to dysbiosis and affect intestinal motility; however, the underlying mechanisms are not fully known. This review aims to discuss the effect of gut microbiota and their metabolites on postoperative intestinal motility, focusing on regulating the enteric nervous system, 5-hydroxytryptamine neurotransmitter, and aryl hydrocarbon receptor.
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页数：11
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