Domino synthesis of novel 3-alkenyl benzofuran derivatives- base mediated condensation cascade reaction

被引：4

作者：

Mundhe, Priyanka ^{[1
]}

Bhanwala, Neeru ^{[1
]}

Saini, Surbhi Mahender ^{[1
]}

Sumanth, Gopavaram ^{[1
]}

Shivaprasad, Kondreddy ^{[1
]}

Reddy, Krishna ^{[1
]}

Chandrashekharappa, Sandeep ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res Raebareli NIPER R, Dept Med Chem, Bijnor Sisendi Rd,Near CRPF Base Camp, Lucknow 226002, Uttar Pradesh, India

来源：

TETRAHEDRON | 2023年 / 132卷

关键词：

3-Alkenyl Benzofuran; Condensation; Transition metal -free; Catalyst; -free; Cascade Reaction; SUBSTITUTED BENZOFURANS; EFFICIENT SYNTHESIS; CYCLIZATION; INHIBITORS; TRANSPORT; SEQUENCE; ANALOGS;

D O I：

10.1016/j.tet.2023.133265

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot and efficient construction method for pharmacologically relevant molecular structures, 3alkenyl benzofuran with excellent yields, has been developed via a green method. Products are obtained from 2-hydroxy chalcone with Phenacyl bromide, Bromo acetonitrile, and/or Ethyl-2-bromo acetate via an alkylation followed by a condensation reaction. This methodology features faster condensation over Michael addition, transition metal, catalyst-free medium, and an environmentally friendly synthetic route toward the synthesis of substituted 3-alkenyl benzofurans. (c) 2023 Elsevier Ltd. All rights reserved.

引用

页数：9

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