SARS-CoV-2/COVID-19 and Hypertensive Pregnancy Disorders: Evaluation of the CRONOS National Registry

被引：5

作者：

Zoellkau, Janine ^{[1
]}

Bohlmann, Michael ^{[2
]}

Mingers, Nina ^{[3
]}

Pecks, Ulrich ^{[3
]}

Weschenfelder, Friederike ^{[1
]}

Groten, Tanja ^{[1
,4
]}

机构：

[1] Univ klinikum Jena, Klin Geburtsmed, Jena, Germany

[2] St Elisabethen Krankenhaus Lorrach gGmbH, Frauenheilkunde & Geburtshilfe, Lorrach, Germany

[3] Univ klinikum Schleswig Holstein Campus Kiel, Klin Gynakol & Geburtshilfe, Jena, Germany

[4] Univ klinikum Jena, Klin Frauenheilkunde & Geburtshilfe, Bachstr 18, D-07743 Jena, Germany

来源：

ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE | 2023年 / 227卷 / 02期

关键词：

SARS-CoV-2; COVID-19; pregnancy; hypertensive pregnancy diseases; preeclampsia; COVID-19;

D O I：

10.1055/a-1962-6964

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

SARS-CoV-2 infection and COVID-19 disease are associated with an increased risk of hypertensive pregnancy disease in international registry studies. Preexisting hypertensive disorders are recognized as a risk factor of severe COVID-19 progression in pregnancy. The respective damage to the endothelium is discussed as a pathophysiological commonality of both diseases. Data of the national CRONOS registry (data status 05/2021; 1104 pregnant women with SARS-CoV-2 infection) were analyzed regarding the association of hypertensive pregnancy disease and maternal, pregnancy, neonatal, and COVID-19 disease outcomes. In the presence of hypertensive pregnancy disease, a severe combined outcome of pregnancy (17.3 vs. 4.3%, p=0.001), mother (25.0 vs. 9.4%, p=0.001), and newborn (28.8 vs. 9.1%, p < 0.0005) occurred significantly more frequent. In contrast, the outcome of COVID-19 disease did not differ (3.8 vs. 7.5%, p=0.424). The co-occurrence of SARS-CoV-2 infection and hypertensive pregnancy disease should be acknowledged as risk factor during management decisions.

引用

页码：120 / 126

页数：7

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