A remnant never forgotten: the utility of circulating tumor DNA in treatment guidance of urachal cancer

被引：1

作者：

Grant, Christopher Ryan ^{[1
]}

Benjamin, David J. ^{[2
]}

Cramer, Scott ^{[3
]}

Rezazadeh Kalebasty, Arash ^{[4
]}

机构：

[1] Univ Calif Irvine, UC Irvine Hlth, Dept Med, Med Ctr, 200 S Manchester Ave,Room 423, Orange, CA 92868 USA

[2] Hoag Family Canc Inst, Newport Beach, CA USA

[3] Univ Calif Irvine, Med Ctr, Dept Radiol, Orange, CA USA

[4] Univ Calif Irvine, Med Ctr, Dept Med, Div Hematol Oncol, Orange, CA USA

来源：

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2024年 / 16卷

关键词：

circulating tumor DNA; urachal cancer; urachal remnant; urachus; CARCINOMA;

D O I：

10.1177/17588359241230743

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Urachal cancer is a rare malignancy of the urachus that is treated with surgical resection if localized and systemic chemotherapy for metastatic disease. Circulating tumor DNA (ctDNA) is a single-stranded or double-stranded DNA released by tumor cells into the blood and harbored the mutations of the original tumor, shedding new light on molecular diagnosis and monitoring of cancer. We report a case of resected localized urachal cancer with clear surgical margins and negative lymph node dissection but elevated ctDNA that progressed to metastatic disease. We also highlight the possibility of using ctDNA levels to assist in adjuvant therapy.

引用

页数：6

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